A Comprehensive Review on Niosomes as a Tool for Advanced Drug Delivery.

Q2 Pharmacology, Toxicology and Pharmaceutics

Pharmaceutical nanotechnology Pub Date : 2024-01-01 DOI:10.2174/2211738511666230726154557

Shivani Sharma, Akash Garg, Rutvi Agrawal, Himansu Chopra, Devender Pathak

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引用次数: 0

Abstract

Over the past few decades, advancements in nanocarrier-based therapeutic delivery have been significant, and niosomes research has recently received much interest. The self-assembled nonionic surfactant vesicles lead to the production of niosomes. The most recent nanocarriers, niosomes, are self-assembled vesicles made of nonionic surfactants with or without the proper quantities of cholesterol or other amphiphilic molecules. Because of their durability, low cost of components, largescale production, simple maintenance, and high entrapment efficiency, niosomes are being used more frequently. Additionally, they enhance pharmacokinetics, reduce toxicity, enhance the solubility of poorly water-soluble compounds, & increase bioavailability. One of the most crucial features of niosomes is their controlled release and targeted diffusion, which is utilized for treating cancer, infectious diseases, and other problems. In this review article, we have covered all the fundamental information about niosomes, including preparation techniques, niosomes types, factors influencing their formation, niosomes evaluation, applications, and administration routes, along with recent developments.

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全面回顾作为先进给药工具的 Niosomes。

过去几十年来，以纳米载体为基础的治疗递送技术取得了重大进展，而niosomes的研究最近也受到了广泛关注。非离子表面活性剂囊泡的自组装导致了 niosomes 的产生。最新的纳米载体--niosomes 是由非离子表面活性剂与或不与适量胆固醇或其他两性分子自组装而成的囊泡。由于其经久耐用、成分成本低、可大规模生产、维护简单、包载效率高等特点，niosomes 正被越来越多地使用。此外，niosomes 还能增强药代动力学、降低毒性、提高水溶性差的化合物的溶解度并增加生物利用度。其中最重要的特点之一是可控释放和定向扩散，可用于治疗癌症、传染病和其他问题。在这篇综述文章中，我们介绍了有关niosomes的所有基本信息，包括制备技术、niosomes类型、影响其形成的因素、niosomes评估、应用、给药途径以及最新进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmaceutical nanotechnology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

4.20

自引率

0.00%

发文量

期刊介绍： Pharmaceutical Nanotechnology publishes original manuscripts, full-length/mini reviews, thematic issues, rapid technical notes and commentaries that provide insights into the synthesis, characterisation and pharmaceutical (or diagnostic) application of materials at the nanoscale. The nanoscale is defined as a size range of below 1 µm. Scientific findings related to micro and macro systems with functionality residing within features defined at the nanoscale are also within the scope of the journal. Manuscripts detailing the synthesis, exhaustive characterisation, biological evaluation, clinical testing and/ or toxicological assessment of nanomaterials are of particular interest to the journal’s readership. Articles should be self contained, centred around a well founded hypothesis and should aim to showcase the pharmaceutical/ diagnostic implications of the nanotechnology approach. Manuscripts should aim, wherever possible, to demonstrate the in vivo impact of any nanotechnological intervention. As reducing a material to the nanoscale is capable of fundamentally altering the material’s properties, the journal’s readership is particularly interested in new characterisation techniques and the advanced properties that originate from this size reduction. Both bottom up and top down approaches to the realisation of nanomaterials lie within the scope of the journal.