Advances in Enzyme-responsive Supramolecular In situ Self-assembled Peptide for Drug Delivery.

IF 2.8 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current drug delivery Pub Date : 2023-07-26 DOI:10.2174/1567201820666230726151607

Wentao Xu, Xiaowen Qin, Yang Liu, Jun Chen, Yuguang Wang

引用次数: 0

Abstract

Because of low immunogenicity, ease of modification, and inherent biosafety, peptides have been well recognized as vehicles to deliver therapeutic agents to targeted regions with improved pharmacokinetic characteristics. Enzyme-responsive self-assembled peptides (ERSAPs) show superiority over their naive forms due to their enhanced targeting efficacy and long-retention property. In this review, we have summarized recent advances in the therapeutic application of ERSAPs, mainly focusing on their self-therapeutic properties and potential as vehicles to deliver different drugs.

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酶反应性超分子原位自组装肽的研究进展。

由于低免疫原性、易于修饰和固有的生物安全性，多肽已被广泛认为是将治疗药物运送到靶向区域的载体，具有改善的药代动力学特征。酶反应型自组装肽(ersap)具有较强的靶向性和较长的滞留性，因此具有较原始形式的优越性。本文综述了近年来erasp在治疗应用方面的研究进展，重点介绍了erasp的自我治疗特性和作为不同药物传递载体的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current drug delivery PHARMACOLOGY & PHARMACY-

CiteScore

5.10

自引率

4.20%

发文量

170

期刊介绍： Current Drug Delivery aims to publish peer-reviewed articles, research articles, short and in-depth reviews, and drug clinical trials studies in the rapidly developing field of drug delivery. Modern drug research aims to build delivery properties of a drug at the design phase, however in many cases this idea cannot be met and the development of delivery systems becomes as important as the development of the drugs themselves. The journal aims to cover the latest outstanding developments in drug and vaccine delivery employing physical, physico-chemical and chemical methods. The drugs include a wide range of bioactive compounds from simple pharmaceuticals to peptides, proteins, nucleotides, nucleosides and sugars. The journal will also report progress in the fields of transport routes and mechanisms including efflux proteins and multi-drug resistance. The journal is essential for all pharmaceutical scientists involved in drug design, development and delivery.