Advantages of mesenchymal stem cell over the other stem cells

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Janani Gopalarethinam , Aswathy P. Nair , Mahalaxmi Iyer , Balachandar Vellingiri , Mohana Devi Subramaniam
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引用次数: 3

Abstract

A stem cell is a particular group of cells that has the extraordinary potential to convert within the body into particular cell types. They are used to regenerate tissues and cells in the body that have been damaged or destroyed by the disease. Stem cells come in three different varieties: adult stem cells, embryonic stem cells and induced pluripotent stem cells (iPSCs). Embryonic stem cells have a high chance of immune rejection and also have ethical dilemmas and iPSCs have genetic instability. Adult stem cells are difficult to analyze and extract for research since they are frequently insufficient in native tissues. However, mesenchymal stem cells (MSC) one of the categories of adult stem cells are stromal cells with a variety of potentials that can differentiate into a wide range of cell types. MSCs can be transplanted into a variety of people without worrying about rejection because they have demonstrated the ability to prevent an adverse reaction from the immune system. These transplants have powerful anti-inflammatory and immunosuppressive effects and greatly enhance the body's inherent healing capacity. While MSCs do not offer treatment for illnesses, the idea behind them is to enable the body to recover sufficiently for a protracted reduction in symptoms. In many cases, this is sufficient to significantly enhance the patient’s well-being. Inspite of several advantages some potential long-term concerns connected to MSC therapy are maldifferentiation, immunosuppression and cancerous tumor growth. In this review, we will compare the mesenchymal stem cells with other stem cells with respect to the source of origin, their properties and therapeutic applications, and discuss the MSC’s disadvantages.

Abstract Image

间充质干细胞相对于其他干细胞的优势
干细胞是一组特殊的细胞,具有在体内转化为特定细胞类型的非凡潜力。它们用于再生体内被疾病损伤或破坏的组织和细胞。干细胞有三种不同的品种:成体干细胞、胚胎干细胞和诱导多能干细胞。胚胎干细胞有很高的免疫排斥几率,也有道德困境,iPSC具有遗传不稳定性。成体干细胞很难分析和提取用于研究,因为它们在天然组织中经常不足。然而,间充质干细胞(MSC)是成人干细胞的一类,是具有多种潜能的基质细胞,可以分化为多种细胞类型。MSCs可以移植到各种人身上,而不用担心排斥反应,因为它们已经证明有能力防止免疫系统的不良反应。这些移植具有强大的抗炎和免疫抑制作用,并大大增强了身体固有的愈合能力。虽然骨髓间充质干细胞不提供疾病治疗,但其背后的理念是使身体能够充分恢复,从而长期减轻症状。在许多情况下,这足以显著提高患者的幸福感。尽管有几个优点,但与MSC治疗相关的一些潜在的长期问题是分化不良、免疫抑制和癌性肿瘤生长。在这篇综述中,我们将比较间充质干细胞与其他干细胞的来源、特性和治疗应用,并讨论MSC的缺点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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