Impacts of MicroRNA-483 on Human Diseases.

IF 3.6 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Non-Coding RNA Pub Date : 2023-06-28 DOI:10.3390/ncrna9040037

Katy Matson, Aaron Macleod, Nirali Mehta, Ellie Sempek, Xiaoqing Tang

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Abstract

MicroRNAs (miRNAs) are short non-coding RNA molecules that regulate gene expression by targeting specific messenger RNAs (mRNAs) in distinct cell types. This review provides a com-prehensive overview of the current understanding regarding the involvement of miR-483-5p and miR-483-3p in various physiological and pathological processes. Downregulation of miR-483-5p has been linked to numerous diseases, including type 2 diabetes, fatty liver disease, diabetic nephropathy, and neurological injury. Accumulating evidence indicates that miR-483-5p plays a crucial protective role in preserving cell function and viability by targeting specific transcripts. Notably, elevated levels of miR-483-5p in the bloodstream strongly correlate with metabolic risk factors and serve as promising diagnostic markers. Consequently, miR-483-5p represents an appealing biomarker for predicting the risk of developing diabetes and cardiovascular diseases and holds potential as a therapeutic target for intervention strategies. Conversely, miR-483-3p exhibits significant upregulation in diabetes and cardiovascular diseases and has been shown to induce cellular apoptosis and lipotoxicity across various cell types. However, some discrepancies regarding its precise function have been reported, underscoring the need for further investigation in this area.

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MicroRNA-483对人类疾病的影响。

微小RNA（miRNA）是一种短的非编码RNA分子，通过靶向不同细胞类型中的特异性信使RNA（mRNA）来调节基因表达。这篇综述对miR-483-5p和miR-483-3p参与各种生理和病理过程的当前理解进行了全面综述。miR-483-5p的下调与许多疾病有关，包括2型糖尿病、脂肪肝、糖尿病肾病和神经损伤。越来越多的证据表明，miR-483-5p通过靶向特定转录物，在保持细胞功能和活力方面发挥着至关重要的保护作用。值得注意的是，血液中miR-483-5p水平的升高与代谢风险因素密切相关，可作为有前景的诊断标志物。因此，miR-483-5p是预测糖尿病和心血管疾病风险的一种有吸引力的生物标志物，有可能成为干预策略的治疗靶点。相反，miR-483-3p在糖尿病和心血管疾病中表现出显著的上调，并已被证明可诱导各种细胞类型的细胞凋亡和脂毒性。然而，据报告，在其确切功能方面存在一些差异，这突出表明需要在这一领域进行进一步调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Non-Coding RNA Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

6.70

自引率

4.70%

发文量

审稿时长

10 weeks

期刊介绍： Functional studies dealing with identification, structure-function relationships or biological activity of: small regulatory RNAs (miRNAs, siRNAs and piRNAs) associated with the RNA interference pathway small nuclear RNAs, small nucleolar and tRNAs derived small RNAs other types of small RNAs, such as those associated with splice junctions and transcription start sites long non-coding RNAs, including antisense RNAs, long ''intergenic'' RNAs, intronic RNAs and ''enhancer'' RNAs other classes of RNAs such as vault RNAs, scaRNAs, circular RNAs, 7SL RNAs, telomeric and centromeric RNAs regulatory functions of mRNAs and UTR-derived RNAs catalytic and allosteric (riboswitch) RNAs viral, transposon and repeat-derived RNAs bacterial regulatory RNAs, including CRISPR RNAS Analysis of RNA processing, RNA binding proteins, RNA signaling and RNA interaction pathways: DICER AGO, PIWI and PIWI-like proteins other classes of RNA binding and RNA transport proteins RNA interactions with chromatin-modifying complexes RNA interactions with DNA and other RNAs the role of RNA in the formation and function of specialized subnuclear organelles and other aspects of cell biology intercellular and intergenerational RNA signaling RNA processing structure-function relationships in RNA complexes RNA analyses, informatics, tools and technologies: transcriptomic analyses and technologies development of tools and technologies for RNA biology and therapeutics Translational studies involving long and short non-coding RNAs: identification of biomarkers development of new therapies involving microRNAs and other ncRNAs clinical studies involving microRNAs and other ncRNAs.