Venous Thromboembolism in Pregnancy: Challenges and Solutions.

IF 2.6 Q2 PERIPHERAL VASCULAR DISEASE

Vascular Health and Risk Management Pub Date : 2023-07-20 eCollection Date: 2023-01-01 DOI:10.2147/VHRM.S404537

Dimitrios Varrias, Michail Spanos, Damianos G Kokkinidis, Panagiotis Zoumpourlis, Dimitrios Rafail Kalaitzopoulos

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Abstract

Venous thromboembolism (VTE) is a serious medical condition that can lead to severe morbidity and mortality, making it a significant public health concern. VTE is a multifactorial condition that results from the interaction of genetic, acquired, and environmental factors. Physiological changes during pregnancy increase the risk of VTE as they express Virchow's triad (increased coagulation factors, decreased fibrinolysis, trauma, and venous stasis). Moreover, pregnancy-related risk factors, such as advanced maternal age, obesity, multiple gestations, and cesarean delivery, further increase the risk of VTE. Managing VTE in pregnancy is challenging due to the complexity of balancing the risks and benefits of anticoagulant therapy for both the mother and the fetus. A multidisciplinary approach involving obstetricians, hematologists, and neonatologists, is necessary to ensure optimal outcomes for both the mother and baby. This review aims to discuss the current challenges associated with VTE in pregnancy and identify potential solutions for improving outcomes for pregnant women at risk for VTE.

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妊娠期静脉血栓栓塞症：挑战与解决方案。

静脉血栓栓塞症（VTE）是一种严重的内科疾病，可导致严重的发病率和死亡率，是一个重大的公共卫生问题。VTE 是一种多因素疾病，是遗传、后天和环境因素相互作用的结果。妊娠期间的生理变化会增加 VTE 的风险，因为它们表现出 Virchow 三联征（凝血因子增加、纤维蛋白溶解减少、创伤和静脉淤血）。此外，与妊娠相关的风险因素，如高龄产妇、肥胖、多胎妊娠和剖宫产，也进一步增加了 VTE 的风险。由于平衡抗凝治疗对母亲和胎儿的风险和益处非常复杂，因此处理妊娠期 VTE 具有挑战性。为确保母亲和胎儿获得最佳治疗效果，有必要采取由产科医生、血液科医生和新生儿科医生共同参与的多学科方法。本综述旨在讨论当前与妊娠期 VTE 相关的挑战，并找出改善有 VTE 风险的孕妇预后的潜在解决方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Vascular Health and Risk Management PERIPHERAL VASCULAR DISEASE-

CiteScore

4.20

自引率

3.40%

发文量

109

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed journal of therapeutics and risk management, focusing on concise rapid reporting of clinical studies on the processes involved in the maintenance of vascular health; the monitoring, prevention, and treatment of vascular disease and its sequelae; and the involvement of metabolic disorders, particularly diabetes. In addition, the journal will also seek to define drug usage in terms of ultimate uptake and acceptance by the patient and healthcare professional.