Strategies and tactics for the synthesis of lipid I and II and shortened analogues: functional building blocks of bacterial cell wall biosynthesis

IF 10.2 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Natural Product Reports Pub Date : 2023-11-15 DOI:10.1039/d3np00018d

Christina Braun , Lukas Martin Wingen , Dirk Menche

引用次数: 0

Abstract

Covering: the literature up to 2022

This study discusses various synthetic strategies for the synthesis of lipid II, the pivotal bacterial cell wall precursor. In detail, it examines different solution phase approaches, reviews various solid phase sequences, and evaluates enzymatic ventures. The underlying rationale, scope, limitations, and perspectives of these strategies are discussed. The focus is on the tactics and strategies towards the authentic peptidoglycan compound, as well as analogues thereof with shortened side chains, which are increasingly recognized as more beneficial surrogates with more favorable physicochemical properties.

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脂质I和II及其缩短类似物的合成策略和策略:细菌细胞壁生物合成的功能构建块。

涵盖:截至2022年的文献。本研究讨论了合成脂质II的各种合成策略，脂质II是关键的细菌细胞壁前体。详细地，它检查不同的溶液相方法，回顾各种固相序列，并评估酶的风险。讨论了这些策略的基本原理、范围、限制和前景。重点是针对真正的肽聚糖化合物的战术和策略，以及其缩短侧链的类似物，它们越来越被认为是更有益的替代品，具有更有利的物理化学性质。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.