Association between hemoglobin variants and laboratory outcomes in patients infected with P. falciparum from South West Uganda.

IF 2.4 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Future Science OA Pub Date : 2023-08-01 DOI:10.2144/fsoa-2022-0067

Hope Onohuean, Fanny Eseohe Onohuean, Ebere Emilia Ayogu

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Abstract

Aims: We assess the relationship between various hemoglobin variants and some hematological parameters packed cell volume, white blood cells (PCV, WBC) and parasitemia level of patients with malaria in the southwestern, Uganda.

Methods: Patient were enrolled by rapid diagnostic tests (RDTs), confirmed by microscopy, and laboratory outcomes were determined.

Results: Patients positive for malaria RDTs were 155, microscopic-confirmed P. falciparum parasites were 95 (61.29%) having hemoglobin variants HbAA and HbAS; 75 (78.95%) and 13 (13.68%), respectively. The laboratory outcomes showed mean, PCV (32.19 ± 4.83), WBC (5831.66 ± 2888.29) and P. falciparum parasitaemia density (32,605.45 ± 14031), while the hemoglobin variants mean values AA (39,008.85 ± 31,261.56), AC (15908 ± 10173.48), AS (16,561.46 ± 15,380.93), SC (30,524 ± 0.000) and SS(1652 ± 0.000) were significantly different from the total population (34,321.5 ± 21,924.26) parasite-density.

Conclusion: Patients with hemoglobin variants HbAA had a significantly higher parasite-carrying capacity and PCV levels.

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乌干达西南部感染恶性疟原虫患者血红蛋白变异与实验室结果之间的关系

目的:评估乌干达西南部疟疾患者各种血红蛋白变异与某些血液学参数、细胞体积、白细胞(PCV、WBC)和寄生虫血症水平之间的关系。方法:采用快速诊断试验(RDTs)入组患者，镜检确诊，并确定实验室结果。结果:疟疾RDTs阳性155例，镜检确诊恶性疟原虫HbAA和HbAS血红蛋白变异95例(61.29%);75例(78.95%)，13例(13.68%)。实验室结果显示，PCV(32.19±4.83)、WBC(5831.66±2888.29)和恶性疟原虫寄生密度(32,605.45±14031)，血红蛋白变异平均值AA(39,008.85±31,261.56)、AC(15908±10173.48)、AS(16,561.46±15,380.93)、SC(30,524±0.000)和SS(1652±0.000)与总人群(34,321.5±21,924.26)的寄生密度存在显著差异。结论:HbAA血红蛋白变异患者携带寄生虫能力和PCV水平明显增高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future Science OA MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

5.00

自引率

4.00%

发文量

审稿时长

13 weeks

期刊介绍： Future Science OA is an online, open access, peer-reviewed title from the Future Science Group. The journal covers research and discussion related to advances in biotechnology, medicine and health. The journal embraces the importance of publishing all good-quality research with the potential to further the progress of research in these fields. All original research articles will be considered that are within the journal''s scope, and have been conducted with scientific rigour and research integrity. The journal also features review articles, editorials and perspectives, providing readers with a leading source of commentary and analysis. Submissions of the following article types will be considered: -Research articles -Preliminary communications -Short communications -Methodologies -Trial design articles -Trial results (including early-phase and negative studies) -Reviews -Perspectives -Commentaries