Lentinan: An unexplored novel biomaterial in drug and gene delivery applications

IF 11.5 1区医学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Journal of Controlled Release Pub Date : 2023-04-01 DOI:10.1016/j.jconrel.2023.02.034

Ankaj Kumar , Rishi Paliwal , Arvind Gulbake

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引用次数: 3

Abstract

Recently, lentinan (LNT) has been utilized for its diversified potential in research with an extended role from nutritional or medicinal applications to a novel biomaterial. LNT is a biocompatible, multifunctional polysaccharide employed as a pharmaceutical additive in engineering customized drug or gene carriers with an improved safety profile. Its triple helical structure containing hydrogen bonding offers more extraordinary binding sites for the attachments of dectin-1 receptors and polynucleotide sequences (poly(dA)). Hence, the diseases expressing dectin-1 receptors can be specifically targeted through so-designed LNT-engineered drug carriers. Gene delivery using poly(dA)-s-LNT complexes and composites has exhibited greater targetability and specificity. The achievement of such gene applications is assessed through the pH and redox potential of the extracellular cell membrane. The steric hindrance-acquiring behavior of LNT shows promise as a system stabilizer in drug carrier engineering. LNT shows viscoelastic gelling behavior temperature-dependently and therefore needs to explore more to meet topical disease applications. The immunomodulatory and vaccine adjuvant properties of LNT help in mitigating viral infections too. This review highlights the new role of LNT as a novel biomaterial, particularly in drug delivery and gene delivery applications. In addition, its importance in achieving various biomedical applications is also discussed.

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香菇多糖:一种未开发的新型生物材料，在药物和基因传递应用

近年来，香菇多糖(LNT)因其多样化的研究潜力而被广泛利用，从营养或药用应用扩展到一种新型生物材料。LNT是一种具有生物相容性的多功能多糖，被用作工程定制药物或基因载体的药物添加剂，具有更高的安全性。其含有氢键的三螺旋结构为dectin-1受体和多核苷酸序列(poly(dA))的附着提供了更多特殊的结合位点。因此，表达dectin-1受体的疾病可以通过设计的lnt工程药物载体特异性靶向。利用poly(dA)-s-LNT复合物和复合材料进行基因传递具有更高的靶向性和特异性。这些基因应用的成就是通过细胞外细胞膜的pH和氧化还原电位来评估的。LNT具有获得位阻的特性，在药物载体工程中具有作为系统稳定剂的应用前景。LNT显示粘弹性胶凝行为的温度依赖性，因此需要探索更多，以满足局部疾病的应用。LNT的免疫调节和疫苗佐剂特性也有助于减轻病毒感染。本文综述了LNT作为一种新型生物材料的新作用，特别是在药物传递和基因传递方面的应用。此外，还讨论了其在实现各种生物医学应用中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Controlled Release 医学-化学综合

CiteScore

18.50

自引率

5.60%

发文量

700

审稿时长

39 days

期刊介绍： The Journal of Controlled Release (JCR) proudly serves as the Official Journal of the Controlled Release Society and the Japan Society of Drug Delivery System. Dedicated to the broad field of delivery science and technology, JCR publishes high-quality research articles covering drug delivery systems and all facets of formulations. This includes the physicochemical and biological properties of drugs, design and characterization of dosage forms, release mechanisms, in vivo testing, and formulation research and development across pharmaceutical, diagnostic, agricultural, environmental, cosmetic, and food industries. Priority is given to manuscripts that contribute to the fundamental understanding of principles or demonstrate the advantages of novel technologies in terms of safety and efficacy over current clinical standards. JCR strives to be a leading platform for advancements in delivery science and technology.