Maternal sodium acetate supplementation promotes lactation performance of sows and their offspring growth performance

IF 6.3
Yingao Qi , Tenghui Zheng , Siwang Yang , Qianzi Zhang , Baofeng Li , Xiangfang Zeng , Yongxing Zhong , Fang Chen , Wutai Guan , Shihai Zhang
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Abstract

Milk yield and composition are critical determining factors for the early growth and development of neonates. The objective of this experiment was to comprehensively evaluate the effects of dietary sodium acetate (SA) supplementation on the milk yield and composition of sows and the growth performance of their offspring. A total of 80 sows (Landrace × Yorkshire, 3 to 6 parity) were randomly assigned to 2 groups (with or without 0.1% SA) from d 85 of gestation to d 21 of lactation. The result shows that maternal 0.1% SA supplementation significantly increased sows milk yield, milk fat, immunoglobulin A (IgA) and IgG content in milk (P < 0.05), with the up-regulation of short-chain fatty acids receptors (GPR41 and GPR43) expression and the activation of mammalian target of rapamycin complex C1 (mTORC1) signaling pathway. Consistently, in our in vitro experiment, SA also activated mTORC1 signaling in porcine mammary epithelial cells (P < 0.05). Furthermore, the improvement of milk quality and quantity caused by maternal SA supplementation led to the increase in body weight (BW) and average daily weight gain (ADG) of weaning piglets, with the improvement of gut health and colonization of the beneficial bacteria (P < 0.05). In conclusion, maternal supplementation of 0.1% SA improved the lactation performance (milk yield and milk fat) of sows, possibly with the activation of GPR41/GPR43-mTORC1 signaling. Furthermore, enhanced milk quality improved growth performance, gut health and the colonization of beneficial microbial flora of their piglets.

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母体补充醋酸钠促进母猪泌乳性能及其后代生长性能
产奶量和成分是新生儿早期生长发育的关键决定因素。本试验的目的是全面评价日粮补充醋酸钠(SA)对母猪产奶量、组成及其后代生长性能的影响。将80头母猪(长白×约克郡,3-6胎次)随机分为2组(含或不含0.1%SA),从妊娠第85天至哺乳第21天。结果表明,母体补充0.1%SA显著增加了母猪的产奶量、乳脂、免疫球蛋白A(IgA)和乳汁中IgG的含量(P<;0.05),同时上调了短链脂肪酸受体(GPR41和GPR43)的表达和哺乳动物雷帕霉素复合物靶点C1(mTORC1)信号通路的激活。一致地,在我们的体外实验中,SA还激活了猪乳腺上皮细胞中的mTORC1信号传导(P<;0.05)。此外,母体补充SA对乳汁质量和数量的改善导致断奶仔猪的体重(BW)和平均日增重(ADG)增加,随着肠道健康和有益细菌定植的改善(P<;0.05)。总之,母体补充0.1%SA改善了母猪的泌乳性能(产奶量和乳脂),可能是通过激活GPR41/GPR43-mTORC1信号。此外,牛奶质量的提高改善了仔猪的生长性能、肠道健康和有益微生物群的定植。
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来源期刊
Animal Nutrition
Animal Nutrition Animal Science and Zoology
CiteScore
9.70
自引率
0.00%
发文量
542
审稿时长
65 days
期刊介绍: Animal Nutrition encompasses the full gamut of animal nutritional sciences and reviews including, but not limited to, fundamental aspects of animal nutrition such as nutritional requirements, metabolic studies, body composition, energetics, immunology, neuroscience, microbiology, genetics and molecular and cell biology related to primarily to the nutrition of farm animals and aquatic species. More applied aspects of animal nutrition, such as the evaluation of novel ingredients, feed additives and feed safety will also be considered but it is expected that such studies will have a strong nutritional focus. Animal Nutrition is indexed in SCIE, PubMed Central, Scopus, DOAJ, etc.
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