Alberto Ciccia, Roger A Greenberg, Susan P Lees-Miller, Andre Nussenzweig
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引用次数: 0
Abstract
To maintain genome fidelity and prevent diseases such as cancer, our cells must constantly detect, and efficiently and precisely repair, DNA damage. Paradoxically, DNA-damaging agents in the form of radiation and chemotherapy are also used to treat cancer. Olivieri et al. used a CRISPR-based screen to identify genes that, when disrupted, lead to sensitivity or resistance to 27 different DNA-damaging agents used in the lab and/or in the clinic to treat cancer patients1. Their results reveal multiple new genes and connections that regulate these critical DNA damage repair pathways, with implications for basic and clinical research as well as cancer therapy.
为了保持基因组的保真度并预防癌症等疾病，我们的细胞必须不断检测并高效、精确地修复 DNA 损伤。矛盾的是，以放疗和化疗为形式的DNA损伤剂也被用来治疗癌症。Olivieri 等人利用基于 CRISPR 技术的筛选，找出了一旦被破坏就会导致对实验室和/或临床上用于治疗癌症患者的 27 种不同 DNA 损伤剂敏感或耐受的基因1。他们的研究结果揭示了调控这些关键 DNA 损伤修复途径的多个新基因和联系，对基础和临床研究以及癌症治疗具有重要意义。
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