Genetic Characteristics of the Virus Detected in the First Mpox Imported Case in Tokyo, Japan.

IF 1.3 4区医学 Q4 INFECTIOUS DISEASES

Japanese journal of infectious diseases Pub Date : 2023-07-24 Epub Date: 2023-03-31 DOI:10.7883/yoken.JJID.2022.546

Fumi Kasuya, Akane Negishi, Ryota Kumagai, Isao Yoshida, Kou Murakami, Takushi Fujiwara, Michiya Hasegawa, Sachiko Harada, Arisa Amano, Makoto Inada, Sho Saito, Shinichiro Morioka, Norio Ohmagari, Yoshiyuki Sugishita, Hirofumi Miyake, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura

{"title":"Genetic Characteristics of the Virus Detected in the First Mpox Imported Case in Tokyo, Japan.","authors":"Fumi Kasuya, Akane Negishi, Ryota Kumagai, Isao Yoshida, Kou Murakami, Takushi Fujiwara, Michiya Hasegawa, Sachiko Harada, Arisa Amano, Makoto Inada, Sho Saito, Shinichiro Morioka, Norio Ohmagari, Yoshiyuki Sugishita, Hirofumi Miyake, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura","doi":"10.7883/yoken.JJID.2022.546","DOIUrl":null,"url":null,"abstract":"<p><p>Mpox, caused by the mpox virus (MPXV), produces symptoms similar to those of smallpox when transmitted to humans. Since 1970, this disease has been endemic, particularly in Africa. However, since May 2022, the number of patients without a history of travel to endemic areas has increased rapidly globally. Under these circumstances, in July 2022, two different real-time PCR methods were used on specimens brought to the Tokyo Metropolitan Institute of Public Health. MPXV was detected in the skin samples, and it was inferred that the virus was a West African strain. Furthermore, a more detailed analysis of the genetic characteristics of the detected MPXV using next-generation sequencing revealed that the MPXV detected in Tokyo was strain B.1, which corresponds to the same strain that is prevalent in Europe and the USA. This suggests that mpox reported for the first time in Japan was imported and related to outbreaks in Europe and the USA. Therefore, it is necessary to continue monitoring outbreaks in Japan in conjunction with global epidemics.</p>","PeriodicalId":14608,"journal":{"name":"Japanese journal of infectious diseases","volume":"76 4","pages":"259-262"},"PeriodicalIF":1.3000,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Japanese journal of infectious diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.7883/yoken.JJID.2022.546","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/3/31 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

Abstract

Mpox, caused by the mpox virus (MPXV), produces symptoms similar to those of smallpox when transmitted to humans. Since 1970, this disease has been endemic, particularly in Africa. However, since May 2022, the number of patients without a history of travel to endemic areas has increased rapidly globally. Under these circumstances, in July 2022, two different real-time PCR methods were used on specimens brought to the Tokyo Metropolitan Institute of Public Health. MPXV was detected in the skin samples, and it was inferred that the virus was a West African strain. Furthermore, a more detailed analysis of the genetic characteristics of the detected MPXV using next-generation sequencing revealed that the MPXV detected in Tokyo was strain B.1, which corresponds to the same strain that is prevalent in Europe and the USA. This suggests that mpox reported for the first time in Japan was imported and related to outbreaks in Europe and the USA. Therefore, it is necessary to continue monitoring outbreaks in Japan in conjunction with global epidemics.

查看原文本刊更多论文

在日本东京第一例猴痘输入病例中检测到的病毒遗传特征。

由猴痘病毒（MPXV）引起的猴痘在传播给人类时会产生类似天花的症状。自1970年以来，这种疾病一直是地方病，特别是在非洲。然而，自2022年5月以来，全球没有去过流行地区旅行史的患者数量迅速增加。在这种情况下，2022年7月，对带到东京都公共卫生研究所的标本使用了两种不同的实时PCR方法。在皮肤样本中检测到MPXV，推断该病毒是西非毒株。此外，使用下一代测序对检测到的MPXV的遗传特征进行更详细的分析显示，在东京检测到的MPXV是菌株B.1，其对应于在欧洲和美国流行的同一菌株。这表明日本首次报告的猴痘是进口的，并与欧洲和美国的疫情有关。因此，有必要结合全球流行病继续监测日本的疫情。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Japanese journal of infectious diseases 医学-传染病学

CiteScore

4.50

自引率

4.50%

发文量

172

审稿时长

2 months

期刊介绍： Japanese Journal of Infectious Diseases (JJID), an official bimonthly publication of National Institute of Infectious Diseases, Japan, publishes papers dealing with basic research on infectious diseases relevant to humans in the fields of bacteriology, virology, mycology, parasitology, medical entomology, vaccinology, and toxinology. Pathology, immunology, biochemistry, and blood safety related to microbial pathogens are among the fields covered. Sections include: original papers, short communications, epidemiological reports, methods, laboratory and epidemiology communications, letters to the editor, and reviews.