Absence of the influence of the APOE gene on the incidence of type 2 diabetes mellitus in a cohort of workers: Effect of diet and shift work

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE
Rocío Mateo-Gallego , Sofía Pérez-Calahorra , Ana M. Bea , Irene Gracia-Rubio , Carmen Rodrigo-Carbo , Belen Moreno-Franco , Fernando Civeira , Martín Laclaustra , Itziar Lamiquiz-Moneo
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引用次数: 0

Abstract

Background

APOE gene encoded a multifunctional protein in lipid metabolism, also associated with inflammatory markers. Type 2 diabetes (T2D) is a complex metabolic disease related to increased blood glucose, triglycerides and VLDL and associated with different dyslipidaemias. The aim of this study was to analyze whether the APOE genotype could determining the risk of developing T2D in a large cohort of workers.

Material and methods

Data from the Aragon Workers Health Study (AWHS) (n = 4895) were used to investigate the relationship between glycemic levels and APOE genotype. All patients in the AWHS cohort had their blood drawn after an overnight fast and laboratory tests were performed on the same day as the blood drawn. Dietary and physical assessment was assessed by face-to-face interview. APOE genotype was determined by the Sanger sequencing method.

Results

The relationship between APOE genotype and glycemic profile showed that glucose, Hb1Ac, insulin and HOMA levels did not seem to be associated with the APOE genotype (p = 0.563, p = 0.605, p = 0.333 and p = 0.276, respectively). In addition, the T2D prevalence did not show an association with the APOE genotype (p = 0.354). Along the same lines, blood glucose levels and T2D prevalence did not show association with the APOE allele. Shift work had some effect on the glycaemic profile, showing that night shift workers have significantly lower levels of glucose, insulin and HOMA (p < 0.001). However, the APOE genotype did not show difference in the concentration of glycaemic parameters adjusting by sex, age and BMI, work shift and dietary parameters.

Conclusion

Glycemic profile and T2D prevalence did not show any significant association with the APOE genotype. Besides, individuals, who worked in non-rotating night shift showed significantly lower glycemic levels, while workers in the morning-afternoon-night shift showed significantly higher values.

缺乏APOE基因对工人队列中2型糖尿病发病率的影响:饮食和轮班工作的影响。
背景:APOE基因在脂质代谢中编码一种多功能蛋白,也与炎症标志物有关。2型糖尿病(T2D)是一种复杂的代谢性疾病,与血糖、甘油三酯和极低密度脂蛋白升高有关,并与不同的血脂异常有关。本研究的目的是分析APOE基因型是否可以决定一大群工人患T2D的风险。材料和方法:使用来自阿拉贡工人健康研究(AWHS)(n=4895)的数据来研究血糖水平与APOE基因型之间的关系。AWHS队列中的所有患者在禁食过夜后都进行了抽血,并在抽血的同一天进行了实验室测试。饮食和身体评估通过面对面访谈进行评估。采用Sanger测序法测定APOE基因型。结果:APOE基因型与血糖谱之间的关系表明,葡萄糖、Hb1Ac、胰岛素和HOMA水平似乎与APOE基因类型无关(分别为0.563、0.605、0.333和0.276)。此外,T2D患病率与APOE基因型无关(p=0.354)。同样,血糖水平和T2D发病率也与APOE等位基因无关。轮班工作对血糖状况有一定影响,表明夜班工人的血糖水平明显较低,胰岛素和HOMA(P结论:血糖谱和T2D患病率与APOE基因型没有任何显著相关性。此外,在非轮班夜班工作的人血糖水平显著较低,而在上午-下午夜班工作的工人血糖水平显著较高。
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来源期刊
Clinica e Investigacion en Arteriosclerosis
Clinica e Investigacion en Arteriosclerosis PERIPHERAL VASCULAR DISEASE-
CiteScore
3.20
自引率
6.20%
发文量
44
审稿时长
40 days
期刊介绍: La publicación idónea para acceder tanto a los últimos originales de investigación como a formación médica continuada sobre la arteriosclerosis y su etiología, epidemiología, fisiopatología, diagnóstico y tratamiento. Además, es la publicación oficial de la Sociedad Española de Arteriosclerosis.
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