Comparison of platelet indices in dengue fever patients based on platelet transfusion: A prospective observational study in a tertiary care center.

IF 0.6 Q4 HEMATOLOGY
Asian Journal of Transfusion Science Pub Date : 2023-01-01 Epub Date: 2022-12-12 DOI:10.4103/ajts.AJTS_24_20
J Asha, Nithya M Baiju, Susheela J Innah, Aboobacker Rafi, Bins M John
{"title":"Comparison of platelet indices in dengue fever patients based on platelet transfusion: A prospective observational study in a tertiary care center.","authors":"J Asha,&nbsp;Nithya M Baiju,&nbsp;Susheela J Innah,&nbsp;Aboobacker Rafi,&nbsp;Bins M John","doi":"10.4103/ajts.AJTS_24_20","DOIUrl":null,"url":null,"abstract":"<p><strong>Context: </strong>Dengue fever is the most prevalent mosquito-borne viral disease in humans. Platelet indices (PIs) are given by the cell counters but are often not reported which is possibly due to under-recognition of the utility of these parameters.</p><p><strong>Aims: </strong>This study aimed to compare PIs in patients with dengue fever to assess their role in the outcome such as hospital stay and platelet transfusion requirements.</p><p><strong>Settings and design: </strong>Prospective observational study in a tertiary care center, Thrissur, Kerala.</p><p><strong>Subjects and methods: </strong>A group of 250 dengue patients was studied over a period of 18 months. The platelet parameters (platelet count, mean platelet volume [MPV], platelet distribution width [PDW], platelet large cell ratio [PLCR], plateletcrit [PCT] and immature platelet fraction [IPF]) were measured with Sysmex XN-1000 and followed up every 24 h. The clinical features, duration of hospital stay and platelet transfusion requirements details were collected.</p><p><strong>Statistical analysis used: </strong>Independent <i>t</i>-test, Chi-square test, Karl Pearson correlation coefficient.</p><p><strong>Results: </strong>A total of sample size was 250. The study showed normal PDW and MPV, low platelet count and PCT, and high PLCR and IPF in dengue patients. There were significant differences in PIs (lower platelet count and PCT, higher MPV, PDW, PLCR, and IPF) in comparison between dengue patients based on platelet transfusion.</p><p><strong>Conclusions: </strong>PIs may act as a predictive tool in the diagnosis and predicting outcomes in dengue fever. Low platelet count and PCT, high PDW, MPV, PLCR, and IPF in transfused dengue patients were found to be statistically significant. Clinicians need to be sensitized about the utility and limitations of these indices and rationalize the need for red cell and platelet transfusions in dengue.</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"17 1","pages":"21-27"},"PeriodicalIF":0.6000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6f/61/AJTS-17-21.PMC10180782.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Transfusion Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ajts.AJTS_24_20","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/12/12 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"HEMATOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Context: Dengue fever is the most prevalent mosquito-borne viral disease in humans. Platelet indices (PIs) are given by the cell counters but are often not reported which is possibly due to under-recognition of the utility of these parameters.

Aims: This study aimed to compare PIs in patients with dengue fever to assess their role in the outcome such as hospital stay and platelet transfusion requirements.

Settings and design: Prospective observational study in a tertiary care center, Thrissur, Kerala.

Subjects and methods: A group of 250 dengue patients was studied over a period of 18 months. The platelet parameters (platelet count, mean platelet volume [MPV], platelet distribution width [PDW], platelet large cell ratio [PLCR], plateletcrit [PCT] and immature platelet fraction [IPF]) were measured with Sysmex XN-1000 and followed up every 24 h. The clinical features, duration of hospital stay and platelet transfusion requirements details were collected.

Statistical analysis used: Independent t-test, Chi-square test, Karl Pearson correlation coefficient.

Results: A total of sample size was 250. The study showed normal PDW and MPV, low platelet count and PCT, and high PLCR and IPF in dengue patients. There were significant differences in PIs (lower platelet count and PCT, higher MPV, PDW, PLCR, and IPF) in comparison between dengue patients based on platelet transfusion.

Conclusions: PIs may act as a predictive tool in the diagnosis and predicting outcomes in dengue fever. Low platelet count and PCT, high PDW, MPV, PLCR, and IPF in transfused dengue patients were found to be statistically significant. Clinicians need to be sensitized about the utility and limitations of these indices and rationalize the need for red cell and platelet transfusions in dengue.

Abstract Image

基于血小板输注的登革热患者血小板指数比较:一项在三级护理中心进行的前瞻性观察研究。
背景:登革热是人类中最常见的蚊子传播的病毒性疾病。血小板指数(PI)由细胞计数器给出,但通常没有报告,这可能是由于对这些参数的效用认识不足。目的:本研究旨在比较登革热患者的PIs,以评估其在住院和血小板输注要求等结果中的作用。设置和设计:喀拉拉邦Thrissur三级护理中心的前瞻性观察性研究。受试者和方法:对250名登革热患者进行为期18个月的研究。用Sysmex XN-1000测量血小板参数(血小板计数、平均血小板体积[MPV]、血小板分布宽度[PDW]、血小板大细胞比率[PCR]、血小板压积[PTC]和未成熟血小板分数[IFP]),并每24小时随访一次。收集临床特征、住院时间和血小板输注要求的详细信息。统计分析采用:独立t检验、卡方检验、Karl-Pearson相关系数。结果:总样本量为250份。研究显示登革热患者PDW和MPV正常,血小板计数和PCT低,PLCR和IPF高。与基于血小板输注的登革热患者相比,PI(较低的血小板计数和PCT,较高的MPV、PDW、PLCR和IPF)存在显著差异。结论:PIs可作为登革热诊断和预测结果的预测工具。输注登革热患者的低血小板计数和PCT、高PDW、MPV、PLCR和IPF具有统计学意义。临床医生需要提高对这些指标的实用性和局限性的认识,并合理化登革热患者对红细胞和血小板输注的需求。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
0.90
自引率
0.00%
发文量
56
审稿时长
44 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信