Microbiota Influences on Hematopoiesis and Blood Cancers: New Horizons?

IF 11.5 Q1 HEMATOLOGY

Blood Cancer Discovery Pub Date : 2023-07-05 DOI:10.1158/2643-3230.BCD-22-0172

Jessica R Galloway-Peña, Christian Jobin

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Abstract

Hematopoiesis governs the generation of immune cells through the differentiation of hematopoietic stem cells (HSC) into various progenitor cells, a process controlled by intrinsic and extrinsic factors. Among extrinsic factors influencing hematopoiesis is the microbiota, or the collection of microorganisms present in various body sites. The microbiota has a profound impact on host homeostasis by virtue of its ability to release various molecules and structural components, which promote normal organ function. In this review, we will discuss the role of microbiota in influencing hematopoiesis and how disrupting the microbiota/host network could lead to hematologic malignancies, as well as highlight important knowledge gaps to move this field of research forward.

Significance: Microbiota dysfunction is associated with many pathologic conditions, including hematologic malignancies. In this review, we discuss the role of microbiota in influencing hematopoiesis and how disrupting the microbiota/host network could lead to hematologic malignancies. Understanding how the microbiota influences hematologic malignancies could have an important therapeutic impact for patients.

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微生物群对造血和血癌的影响：新视野？

造血是通过造血干细胞（HSC）分化成各种祖细胞来产生免疫细胞的，这一过程受内在和外在因素的控制。影响造血的外在因素包括微生物群，即存在于人体各个部位的微生物集合。微生物群能够释放各种分子和结构成分，促进器官的正常功能，因此对宿主的平衡有着深远的影响。在这篇综述中，我们将讨论微生物群在影响造血过程中的作用，以及破坏微生物群/宿主网络如何导致血液系统恶性肿瘤，并强调推动这一研究领域发展的重要知识缺口：微生物群功能失调与包括血液系统恶性肿瘤在内的许多病理状况有关。在这篇综述中，我们讨论了微生物群在影响造血过程中的作用，以及破坏微生物群/宿主网络如何导致血液恶性肿瘤。了解微生物群如何影响血液恶性肿瘤可能会对患者产生重要的治疗影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Blood Cancer Discovery Multiple-

CiteScore

12.70

自引率

1.80%

发文量

139

期刊介绍： The journal Blood Cancer Discovery publishes high-quality Research Articles and Briefs that focus on major advances in basic, translational, and clinical research of leukemia, lymphoma, myeloma, and associated diseases. The topics covered include molecular and cellular features of pathogenesis, therapy response and relapse, transcriptional circuits, stem cells, differentiation, microenvironment, metabolism, immunity, mutagenesis, and clonal evolution. These subjects are investigated in both animal disease models and high-dimensional clinical data landscapes. The journal also welcomes submissions on new pharmacological, biological, and living cell therapies, as well as new diagnostic tools. They are interested in prognostic, diagnostic, and pharmacodynamic biomarkers, and computational and machine learning approaches to personalized medicine. The scope of submissions ranges from preclinical proof of concept to clinical trials and real-world evidence. Blood Cancer Discovery serves as a forum for diverse ideas that shape future research directions in hematooncology. In addition to Research Articles and Briefs, the journal also publishes Reviews, Perspectives, and Commentaries on topics of broad interest in the field.