Inguinal lymphadenectomy in penile cancer patients: a comparison between open and video endoscopic approach in a multicenter setting.

Q3 Pharmacology, Toxicology and Pharmaceutics

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2023-03-20 eCollection Date: 2023-05-01 DOI:10.1515/jbcpp-2023-0038

Maida Bada, Felice Crocetto, Peter Nyirady, Vincenzo Pagliarulo, Sebastiano Rapisarda, Antonio Aliberti, Stefano Boccasile, Matteo Ferro, Biagio Barone, Antonio Celia

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引用次数: 0

Abstract

Objectives: To compare differences of operative outcomes, post-operative complications and survival outcomes between open and laparoscopic cases in a multicenter study.

Methods: This was a retrospective cohort study performed at three European centers from September 2011 to January 2019. The surgeon decision to perform open inguinal lymphadenectomy (OIL) or video endoscopic inguinal lymphadenectomy (VEIL) was done in each hospital after patient counselling. Inclusion criteria regarded a minimum follow-up of 9 months since the inguinal lymphadenectomy.

Results: A total of 55 patients with proven squamous cell penile cancer underwent inguinal lymphadenectomy. 26 of them underwent OIL, while 29 patients underwent VEIL. For the OIL and VEIL groups, the mean operative time was 2.5 vs. 3.4 h (p=0.129), respectively. Hospital stays were lower in the VEIL group with 4 vs. 8 days in OIL patients (p=0.053) while number of days requiring drains to remain in situ was 3 vs. 6 days (p=0.024). The VEIL group reported a lower incidence of major complications compared to the OIL group (2 vs. 17%, p=0.0067) while minor complications were comparable in both groups. In a median follow-up period of 60 months, the overall survival was 65.5 and 84.6% in OIL and VEIL groups, respectively (p=0.105).

Conclusions: VEIL is comparable to OIL regarding safety, overall survival and post-operative outcomes.

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阴茎癌患者腹股沟淋巴结切除术：开放式和视频内窥镜方法在多中心环境中的比较。

目的在一项多中心研究中比较开腹手术和腹腔镜手术的手术效果、术后并发症和存活率的差异：这是一项回顾性队列研究，于 2011 年 9 月至 2019 年 1 月在三个欧洲中心进行。每家医院在对患者进行咨询后，由外科医生决定实施开放式腹股沟淋巴结切除术（OIL）或视频内镜腹股沟淋巴结切除术（VEIL）。纳入标准为腹股沟淋巴结切除术后至少随访 9 个月：共有 55 名已证实患有阴茎鳞状细胞癌的患者接受了腹股沟淋巴结切除术。其中 26 人接受了 OIL，29 人接受了 VEIL。OIL组和VEIL组的平均手术时间分别为2.5小时和3.4小时（P=0.129）。VEIL组的住院时间较短，OIL组为4天，VEIL组为8天（P=0.053），需要在原位留置引流管的天数为3天，OIL组为6天（P=0.024）。VEIL 组的主要并发症发生率低于 OIL 组（2% 对 17%，P=0.0067），而两组的轻微并发症发生率相当。中位随访期为60个月，OIL组和VEIL组的总生存率分别为65.5%和84.6%（P=0.105）：结论：在安全性、总生存率和术后效果方面，VEIL与OIL相当。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Basic and Clinical Physiology and Pharmacology Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

3.90

自引率

0.00%

发文量

期刊介绍： The Journal of Basic and Clinical Physiology and Pharmacology (JBCPP) is a peer-reviewed bi-monthly published journal in experimental medicine. JBCPP publishes novel research in the physiological and pharmacological sciences, including brain research; cardiovascular-pulmonary interactions; exercise; thermal control; haematology; immune response; inflammation; metabolism; oxidative stress; and phytotherapy. As the borders between physiology, pharmacology and biochemistry become increasingly blurred, we also welcome papers using cutting-edge techniques in cellular and/or molecular biology to link descriptive or behavioral studies with cellular and molecular mechanisms underlying the integrative processes. Topics: Behavior and Neuroprotection, Reproduction, Genotoxicity and Cytotoxicity, Vascular Conditions, Cardiovascular Function, Cardiovascular-Pulmonary Interactions, Oxidative Stress, Metabolism, Immune Response, Hematological Profile, Inflammation, Infection, Phytotherapy.