Effects of electroacupuncture on liver function in mice with chronic alcoholic liver injury: visual display by in vivo fluorescence imaging.

IF 2.4 3区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Acupuncture in Medicine Pub Date : 2023-08-01 DOI:10.1177/09645284221125248

Xiao-Jing Song, Shu-You Wang, Shu-Yong Jia, Guang-Jun Wang, Wei-Bo Zhang

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引用次数: 0

Abstract

Objective: Acupuncture can improve the symptoms of alcohol-induced bodily injury and has been accepted by the World Health Organization. In this study, in vivo fluorescence imaging (IVFI) was applied to display and evaluate the effect of electroacupuncture (EA) on liver function (LF) in mice with chronic alcoholic liver injury (cALI).

Methods: IVFI of the Cy5.5-galactosylated polylysine (Cy5.5-GP) probe targeting the liver asialoglycoprotein receptor (ASGPR) and liver indocyanine green (ICG) clearance was performed to visually evaluate the effect of EA at ST36 and BL18 on liver reserve function and hepatic metabolism in mice with cALI. In addition, changes in ASGPR expression, serum indexes of LF, and hepatic morphology were observed.

Results: After EA at ST36 and BL18, the ASGPR-targeted fluorescence signals (FS) in the liver increased significantly in cALI mice (p < 0.05) and exhibited relationships with liver ASGPR expression, liver ICG clearance, liver histology, and serum marker levels of LF in cALI mice undergoing EA intervention.

Conclusions: As displayed by IVFI, EA at ST36 and BL18 appears to improve liver reserve function and inhibit the development of liver injury in mice with cALI. EA may have potential as a treatment strategy to protect against ALI.

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电针对慢性酒精性肝损伤小鼠肝功能的影响:体内荧光成像的视觉显示。

目的:针灸可改善酒精性身体损伤的症状，已被世界卫生组织认可。本研究采用活体荧光成像技术(IVFI)显示和评价电针(EA)对慢性酒精性肝损伤(cALI)小鼠肝功能(LF)的影响。方法:采用体外显像法(IVFI)检测靶向肝asialal糖蛋白受体(ASGPR)和肝脏吲哚菁绿(ICG)清除的cy5.5 -半乳糖基化聚赖氨酸(Cy5.5-GP)探针，目测EA在ST36和BL18处对cALI小鼠肝脏储备功能和肝脏代谢的影响。观察ASGPR表达、血清LF指标及肝脏形态学的变化。结果:在ST36和BL18处EA后，cALI小鼠肝脏中asgpr靶向荧光信号(FS)明显增加(p)。结论:IVFI显示，ST36和BL18处EA可改善cALI小鼠肝脏储存功能，抑制肝损伤的发展。EA可能有潜力作为预防ALI的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acupuncture in Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

4.70

自引率

4.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Acupuncture in Medicine aims to promote the scientific understanding of acupuncture and related treatments by publishing scientific investigations of their effectiveness and modes of action as well as articles on their use in health services and clinical practice. Acupuncture in Medicine uses the Western understanding of neurophysiology and anatomy to interpret the effects of acupuncture.