Eddie W Fakhouri, Stephen J Peterson, William Fakhouri, Ruth Minkin, William H Frishman, Jeremy A Weingarten
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引用次数: 0
Abstract
Obstructive sleep apnea (OSA) is highly prevalent and associated with oxidative stress, chronic inflammation, and adverse cardiovascular consequences. The comorbid condition of obesity remains epidemic. Both obesity and OSA are highly comorbid in patients with cardiovascular disease including atrial fibrillation, resistant hypertension, congestive heart failure, and coronary artery disease. Patients with these preexisting cardiovascular conditions should be screened for OSA with a low threshold to treat, even if OSA severity is mild. Nephroblastoma overexpressed (NOV/CCN3) protein has been identified in multiple chronic inflammatory states, most notably in obesity and more recently in OSA, even in the absence of obesity. As such, NOV may represent an important biomarker for oxidative stress in OSA and may lead to a deeper understanding of the relationship between OSA and its clinical sequelae.
阻塞性睡眠呼吸暂停（OSA）发病率很高，与氧化应激、慢性炎症和不良心血管后果有关。肥胖症仍然是一种流行病。肥胖和 OSA 都是心血管疾病患者的高合并症，包括心房颤动、抵抗性高血压、充血性心力衰竭和冠状动脉疾病。对患有这些原有心血管疾病的患者应进行 OSA 筛查，即使 OSA 的严重程度较轻，也应降低治疗门槛。肾母细胞瘤过表达（NOV/CCN3）蛋白已在多种慢性炎症状态中被发现，最明显的是在肥胖症中，最近又在 OSA 中被发现，即使没有肥胖症。因此，NOV 可能是 OSA 中氧化应激的一个重要生物标志物，可帮助人们更深入地了解 OSA 及其临床后遗症之间的关系。
期刊介绍：
The mission of Cardiology in Review is to publish reviews on topics of current interest in cardiology that will foster increased understanding of the pathogenesis, diagnosis, clinical course, prevention, and treatment of cardiovascular disorders. Articles of the highest quality are written by authorities in the field and published promptly in a readable format with visual appeal
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