The ubiquitin codes in cellular stress responses.

IF 13.6 1区 生物学 Q1 CELL BIOLOGY
Xiangpeng Sheng, Zhixiong Xia, Hanting Yang, Ronggui Hu
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引用次数: 0

Abstract

Ubiquitination/ubiquitylation, one of the most fundamental post-translational modifications, regulates almost every critical cellular process in eukaryotes. Emerging evidence has shown that essential components of numerous biological processes undergo ubiquitination in mammalian cells upon exposure to diverse stresses, from exogenous factors to cellular reactions, causing a dazzling variety of functional consequences. Various forms of ubiquitin signals generated by ubiquitylation events in specific milieus, known as ubiquitin codes, constitute an intrinsic part of myriad cellular stress responses. These ubiquitination events, leading to proteolytic turnover of the substrates or just switch in functionality, initiate, regulate, or supervise multiple cellular stress-associated responses, supporting adaptation, homeostasis recovery, and survival of the stressed cells. In this review, we attempted to summarize the crucial roles of ubiquitination in response to different environmental and intracellular stresses, while discussing how stresses modulate the ubiquitin system. This review also updates the most recent advances in understanding ubiquitination machinery as well as different stress responses and discusses some important questions that may warrant future investigation.

细胞应激反应中的泛素密码。
泛素化/泛素化是最基本的翻译后修饰之一,几乎调节着真核生物的所有关键细胞过程。新的证据表明,哺乳动物细胞在受到从外源因子到细胞反应等各种压力时,许多生物过程的重要成分都会发生泛素化,从而导致令人眼花缭乱的各种功能性后果。在特定环境中泛素化事件产生的各种形式的泛素信号,即泛素密码,构成了无数细胞应激反应的内在组成部分。这些泛素化事件导致底物的蛋白水解周转或功能转换,启动、调节或监督多种细胞应激相关反应,支持应激细胞的适应、稳态恢复和存活。在这篇综述中,我们试图总结泛素化在应对不同环境和细胞内压力时的关键作用,同时讨论压力如何调节泛素系统。本综述还更新了在理解泛素化机制以及不同应激反应方面的最新进展,并讨论了未来可能需要研究的一些重要问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Protein & Cell
Protein & Cell CELL BIOLOGY-
CiteScore
24.00
自引率
0.90%
发文量
1029
审稿时长
6-12 weeks
期刊介绍: Protein & Cell is a monthly, peer-reviewed, open-access journal focusing on multidisciplinary aspects of biology and biomedicine, with a primary emphasis on protein and cell research. It publishes original research articles, reviews, and commentaries across various fields including biochemistry, biophysics, cell biology, genetics, immunology, microbiology, molecular biology, neuroscience, oncology, protein science, structural biology, and translational medicine. The journal also features content on research policies, funding trends in China, and serves as a platform for academic exchange among life science researchers.
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