Diagnostic accuracy of interleukin-2 receptor in sarcoidosis: a systematic review and meta-analysis.

IF 2.9 3区医学 Q2 RESPIRATORY SYSTEM

Expert Review of Respiratory Medicine Pub Date : 2023-01-01 Epub Date: 2023-06-23 DOI:10.1080/17476348.2023.2225772

Dan Qin, Li-Li Fan, Yuxia Zhong, Yongchun Shen, Deyun Cheng

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引用次数: 0

Abstract

Introduction: Soluble interleukin-2 receptor (sIL-2 R), a valuable diagnostic biomarker for sarcoidosis, has been reported with variable results. Based on the literatures currently accessible, a systematic review and meta-analysis of the diagnostic performance of serum sIL-2 R for sarcoidosis were performed.

Methods: Relevant studies investigating sIL-2 R for sarcoidosis diagnosis in several databases were searched and data on sensitivity, speciﬁcity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) were pooled by STATA 16.0 software. Overall test performance was assessed using summary receiver operating characteristic curves and the area under the curve (AUC). Potential publication bias was assessed by Deeks test.

Results: We included eleven studies involving 1,424 subjects, with 1,099 cases of sarcoidosis and 325 of non-sarcoidosis. The pooled parameters of sIL-2 R in diagnosing sarcoidosis were summarized as follows: sensitivity, 0.85 (95% CI: 0.72-0.93); specificity, 0.88 (95% CI: 0.72-0.96); PLR, 7.3 (95% CI: 2.7-20.1); NLR, 0.17 (95% CI:0.08-0.36); DOR, 44 (95% CI: 8-231); and the AUC, 0.93 (95% CI: 0.90-0.95). No publication bias was identified (P = 0.64).

Conclusions: Evidence suggests sIL-2 R performs well in diagnosing sarcoidosis. Nevertheless, results of sIL-2 R assay should be interpreted with other diagnostic examinations.

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白细胞介素2受体在结节病中的诊断准确性：一项系统综述和荟萃分析。

简介：可溶性白细胞介素2受体 R），一种有价值的结节病诊断生物标志物，已被报道，结果各异。基于现有文献，对血清sIL-2的诊断性能进行系统综述和荟萃分析对结节病进行了R检查。方法：sIL-2的相关研究在几个数据库中搜索结节病诊断的R，并通过STATA 16.0软件汇总敏感性、特异性、阳性似然比（PLR）、阴性似然比（NLR）和诊断优势比（DOR）的数据。使用总结受试者工作特性曲线和曲线下面积（AUC）评估总体测试性能。Deeks检验评估了潜在的发表偏倚。结果：我们纳入了11项研究，涉及1424名受试者，其中1099例为结节病，325例为非结节病。sIL-2的合并参数诊断结节病的R值总结如下：敏感性0.85（95%可信区间：0.72-0.93）；特异性，0.88（95%可信区间：0.72-0.96）；PLR，7.3（95%CI:2.7-20.1）；NLR为0.17（95%CI:0.08-0.36）；DOR，44（95%CI:8-231）；AUC为0.93（95%CI:0.90-0.95）。未发现发表偏倚（P = 0.64）。结论：有证据表明sIL-2 R在诊断结节病方面表现良好。然而，sIL-2的结果 R测定应与其他诊断检查一起进行解释。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Respiratory Medicine RESPIRATORY SYSTEM-

CiteScore

6.80

自引率

2.60%

发文量

期刊介绍： Coverage will include the following key areas: - Prospects for new and emerging therapeutics - Epidemiology of disease - Preventive strategies - All aspects of COPD, from patient self-management to systemic effects of the disease and comorbidities - Improved diagnostic methods, including imaging techniques, biomarkers and physiological tests. - Advances in the treatment of respiratory infections and drug resistance issues - Occupational and environmental factors - Progress in smoking intervention and cessation methods - Disease and treatment issues for defined populations, such as children and the elderly - Respiratory intensive and critical care - Updates on the status and advances of specific disease areas, including asthma, HIV/AIDS-related disease, cystic fibrosis, COPD and sleep-disordered breathing morbidity