Redox-Neutral Decarboxylative and Desulfonylative C(sp3) Trifluoromethylation: Method Development and Mechanistic Inquiry.

Abstract

Sodium triflinate (CF₃SO₂Na) is an inexpensive bench-stable radical CF₃ source that is often activated by external oxidants such as peroxides. However, despite the commercial accessibility of CF₃SO₂Na, the salt has never been applied to decarboxylative trifluoromethylation due to challenges in controlled cross-radical coupling. We report a redox-neutral approach to decarboxylative C(sp³) trifluoromethylation of carboxylic acid derivatives. Mechanistic inquiry is performed to address the limitations in scope.