Establishment of reference intervals for bone turnover markers in healthy Chinese older adults.

IF 1.2 4区医学 Q2 ANTHROPOLOGY

Annals of Human Biology Pub Date : 2023-02-01 DOI:10.1080/03014460.2023.2187456

Li-Li Sun, Rong-Rong Cao, Jin-Di Wang, Guo-Long Zhang, Fei-Yan Deng, Shu-Feng Lei

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引用次数: 1

Abstract

Background: Reference ranges for bone turnover markers (BTMs) are still lacking in the healthy Chinese population.

Aim: To establish reference intervals for BTMs and to investigate the correlations between BTMs and bone mineral density (BMD) in Chinese older adults.

Subjects and methods: A community-based cross-sectional study was conducted among 2511 Chinese subjects aged over 50 yrs residing in Zhenjiang, Southeast China. Reference intervals for BTMs (i.e. procollagen type I N-terminal propeptide, P1NP; β cross-linked C-terminal telopeptide of type I collagen, β-CTX) were calculated as the central 95% range of all measurements in Chinese older adults.

Results: The reference intervals of P1NP, β-CTX and P1NP/β-CTX were 15.8-119.9 ng/mL, 0.041-0.675 ng/mL and 49.9-1261.5 for females and 13.6-111.4 ng/mL, 0.038-0.627 ng/mL and 41.0-1269.1 for males, respectively. In the multiple linear regression analysis, only β-CTX was negatively associated with BMD after adjusting for age and body mass index (BMI) in both sex-stratified groups (all p < .05).

Conclusion: This study established age- and sex-specific reference intervals for BTMs in a large sample of healthy Chinese participants ≥ 50 and < 80 years of age and explored the correlations between BTMs and BMD, which provides an effective reference for the assessment of bone turnover in the clinical practice of osteoporosis.

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中国健康老年人骨转换指标参考区间的建立

背景:骨转换标志物(BTMs)的参考范围在中国健康人群中仍然缺乏。目的:建立中国老年人脑tm的参考区间，探讨脑tm与骨密度(BMD)的相关性。对象与方法:采用社区为基础的横断面研究方法，对中国东南部镇江市2511名年龄在50岁以上的中国居民进行调查。btm的参考区间(即前胶原I型n端前肽，P1NP;计算I型胶原β交联c末端末端肽(β- ctx)作为中国老年人所有测量的中心95%范围。结果:女性P1NP、β-CTX和P1NP/β-CTX的参考区间分别为15.8 ~ 119.9 ng/mL、0.041 ~ 0.675 ng/mL和49.9 ~ 1261.5;男性P1NP/β-CTX的参考区间分别为13.6 ~ 111.4 ng/mL、0.038 ~ 0.627 ng/mL和41.0 ~ 1269.1。在多元线性回归分析中，在性别分层组中，只有β-CTX在调整年龄和体重指数(BMI)后与BMD呈负相关(均p)。本研究在年龄≥50岁和< 80岁的中国健康大样本中建立了BTMs的年龄和性别特异性参考区间，探讨了BTMs与骨密度的相关性，为骨质疏松症临床实践中评估骨转换提供了有效参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Human Biology 生物-公共卫生、环境卫生与职业卫生

CiteScore

3.40

自引率

5.90%

发文量

审稿时长

1 months

期刊介绍： Annals of Human Biology is an international, peer-reviewed journal published six times a year in electronic format. The journal reports investigations on the nature, development and causes of human variation, embracing the disciplines of human growth and development, human genetics, physical and biological anthropology, demography, environmental physiology, ecology, epidemiology and global health and ageing research.