Increased Risk of Rheumatoid Arthritis in Patients With Asthma: A Genetic Association Study Using Two-Sample Mendelian Randomization Analysis

IF 3.7 2区医学 Q1 RHEUMATOLOGY

Arthritis Care & Research Pub Date : 2023-07-19 DOI:10.1002/acr.25193

Jiyuan Yan, Yi Zhang, Xiaofei Zhang, Ge Chen, Daiqing Wei, Ke Duan, Zheng Li, Lin Peng, Jialin Liu, Zhong Li, Yanshi Liu

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引用次数: 0

Abstract

Objective

Observational studies have explored the association between asthma and some types of arthritis, including rheumatoid arthritis and osteoarthritis, but the results are largely contradictory. We aimed to investigate the causal effects of asthma on arthritis, including osteoarthritis, rheumatoid arthritis, gout, and ankylosing spondylitis.

Methods

Two-sample Mendelian randomization (MR) analysis was used to investigate the causal effects of asthma on each arthritis. The genetic instruments for asthma were obtained from a large genome-wide association study of asthma. The inverse-variance weighted (IVW) method was used as the main analysis of MR. Bonferroni-adjusted P value threshold was used to account for multiple comparisons.

Results

MR-IVW analysis suggested that adult-onset asthma (AOA) was associated with increased risk of rheumatoid arthritis. The odds ratio for rheumatoid arthritis associated with AOA and childhood-onset asthma (COA) were 1.018 (95% confidence interval [95% CI], 1.011–1.025; P < 0.001) and 1.006 (95% CI 1.001–1.012; P = 0.046), respectively. For osteoarthritis, gout, or ankylosing spondylitis, all the MR analyses showed no significant causal effects of AOA or COA on them. We also performed a reverse MR analysis to explore the causal effects of rheumatoid on all asthma, allergic asthma, or nonallergic asthma and found no significant causal effects on them.

Conclusion

Genetically predicted AOA predisposes patients to an increased risk of rheumatoid arthritis but has no causal effects on osteoarthritis, gout, and ankylosing spondylitis. The result of COA on rheumatoid arthritis is suggestive of potential causal relationship but needs to be confirmed in further studies.

Abstract Image

查看原文本刊更多论文

哮喘患者患类风湿性关节炎的风险增加：一项使用两样本孟德尔随机化分析的遗传关联研究。

目的：观察性研究探讨了哮喘与某些类型的关节炎之间的关系，包括类风湿性关节炎和骨关节炎，但结果在很大程度上是矛盾的。我们旨在研究哮喘对关节炎的因果影响，包括骨关节炎、类风湿性关节炎、痛风和强直性脊柱炎。方法：采用两样本孟德尔随机化（MR）分析来研究哮喘对每种关节炎的因果影响。哮喘的遗传仪器是从一项大规模的哮喘全基因组关联研究中获得的。反方差加权（IVW）方法被用作MR的主要分析。Bonferroni调整的P值阈值被用于解释多重比较。结果：MR-IVW分析表明，成人哮喘（AOA）与类风湿性关节炎的风险增加有关。与AOA和儿童哮喘（COA）相关的类风湿性关节炎的比值比为1.018（95%置信区间[95%CI]，1.011-1.025；P结论：基因预测的AOA易使患者患类风湿性关节炎的风险增加，但对骨关节炎、痛风和强直性脊柱炎没有因果影响。COA治疗类风湿性关节炎的结果提示了潜在的因果关系，但需要在进一步的研究中得到证实。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arthritis Care & Research RHEUMATOLOGY-

CiteScore

9.40

自引率

6.40%

发文量

368

审稿时长

3-6 weeks

期刊介绍： Arthritis Care & Research, an official journal of the American College of Rheumatology and the Association of Rheumatology Health Professionals (a division of the College), is a peer-reviewed publication that publishes original research, review articles, and editorials that promote excellence in the clinical practice of rheumatology. Relevant to the care of individuals with rheumatic diseases, major topics are evidence-based practice studies, clinical problems, practice guidelines, educational, social, and public health issues, health economics, health care policy, and future trends in rheumatology practice.