Autoimmune-mediated astrocytopathy.

IF 5 3区医学 Q2 IMMUNOLOGY

Inflammation and Regeneration Pub Date : 2023-07-18 DOI:10.1186/s41232-023-00291-5

Makoto Kinoshita, Tatsusada Okuno

引用次数: 0

Abstract

Recently accumulating evidence identified the disease entity where astrocytes residing within the central nervous system (CNS) are the target of autoantibody-mediated autoimmunity. Aquaporin4 (AQP4) is the most common antigen to serve as astrocyte-targeted autoimmune responses. Here, in this review, the clinical and pathological aspects of AQP4-mediated astrocyte disease are discussed together with the pathogenic role of anti-AQP4 antibody. More recently, the mechanism of immune dysregulation resulting in the production of astrocyte-targeted autoantibody is also revealed, and the postulated hypothesis is discussed.

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谷蛋白astrocytopathy。

最近越来越多的证据表明，中枢神经系统内的星形胶质细胞是自身抗体介导的自身免疫的目标。水通道蛋白4 (AQP4)是星形胶质细胞靶向自身免疫反应中最常见的抗原。本文就aqp4介导的星形细胞病的临床和病理方面以及抗aqp4抗体的致病作用进行综述。最近，免疫失调导致星形胶质细胞靶向自身抗体产生的机制也被揭示，并讨论了假设的假设。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Inflammation and Regeneration Multiple-

CiteScore

11.10

自引率

1.20%

发文量

审稿时长

11 weeks

期刊介绍： Inflammation and Regeneration is the official journal of the Japanese Society of Inflammation and Regeneration (JSIR). This journal provides an open access forum which covers a wide range of scientific topics in the basic and clinical researches on inflammation and regenerative medicine. It also covers investigations of infectious diseases, including COVID-19 and other emerging infectious diseases, which involve the inflammatory responses. Inflammation and Regeneration publishes papers in the following categories: research article, note, rapid communication, case report, review and clinical drug evaluation.