Abnormal expression and role of MicroRNA-214-3p/SLC8A1 in neonatal Hypoxic-Ischaemic encephalopathy

IF 1.8 4区 医学 Q3 PATHOLOGY
Liu Yang, Li Zhang, Jing Zhu, Yuqian Wang, Ning Zou, Zhengjuan Liu, Yingjie Wang
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引用次数: 1

Abstract

Neonatal hypoxic-ischaemic encephalopathy (HIE) refers to brain damage caused by intra-uterine distress and asphyxia/hypoxia during the perinatal and neonatal periods. MicroRNA (MiR)-214-3p plays a critical role in cell growth and apoptosis. The aim of this study was to investigate the expression and role of miR-214-3p in neonatal HIE development, and to explore the underlying mechanisms. The expression of miR-214-3p was significantly down-regulated, while that of Slc8a1, a direct target of miR-214-3p, was significantly up-regulated, in the brain tissue of neonatal HIE rats. The over-expression of miR-214-3p promoted the proliferation and inhibited the apoptosis of neurones, while its down-regulation had the opposite effect. Our results indicate that miR-214-3p expression was down-regulated in neonatal HIE rats, and the up-regulation of miR-214-3p expression protected against HIE development by inhibiting neuronal apoptosis.

Abstract Image

MicroRNA-214-3p/SLC8A1在新生儿缺氧缺血性脑病中的异常表达及其作用
新生儿缺氧缺血性脑病(HIE)是指围产期和新生儿期因宫内窘迫和窒息/缺氧引起的脑损伤。MicroRNA (MiR)-214-3p在细胞生长和凋亡中起关键作用。本研究的目的是研究miR-214-3p在新生儿HIE发展中的表达和作用,并探讨其潜在机制。新生儿HIE大鼠脑组织中miR-214-3p的表达显著下调,miR-214-3p的直接靶点Slc8a1的表达显著上调。过表达miR-214-3p可促进神经元的增殖,抑制神经元的凋亡,而下调miR-214-3p则相反。我们的研究结果表明,miR-214-3p在新生儿HIE大鼠中表达下调,miR-214-3p表达上调通过抑制神经元凋亡来保护HIE的发展。
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来源期刊
CiteScore
4.50
自引率
3.30%
发文量
35
审稿时长
>12 weeks
期刊介绍: Experimental Pathology encompasses the use of multidisciplinary scientific techniques to investigate the pathogenesis and progression of pathologic processes. The International Journal of Experimental Pathology - IJEP - publishes papers which afford new and imaginative insights into the basic mechanisms underlying human disease, including in vitro work, animal models, and clinical research. Aiming to report on work that addresses the common theme of mechanism at a cellular and molecular level, IJEP publishes both original experimental investigations and review articles. Recent themes for review series have covered topics as diverse as "Viruses and Cancer", "Granulomatous Diseases", "Stem cells" and "Cardiovascular Pathology".
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