Apoptotic Switch in Cancer Stem Cells: A Potential Approach for Cancer Treatment.

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Vinoth Prasanna Gunasekaran, Thirunavukkarasu Sivaraman, Mathan Ganeshan
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引用次数: 0

Abstract

Cancer diseases account for about 15% of deaths globally right now, and the percentage may increase in the future. There are more than 100 types of cancer, and each of them is distinct in its origin, microenvironment, growth, metastasis, and signalling pathways. Cancer stem cells are the specialised cells that make cancer more aggressive and difficult to treat. Moreover, cancer aetiology may exist at the genomic, proteomic, or habitat level in any combination. Hence, a unanimous treatment protocol for the different cancers is an uphill task at the present juncture. In this context, this review aims to provide a comprehensive reappraisal concisely of anti-apoptotic proteins, which are shown to be overexpressed in most cancers, if not all, and to forthrightly rationalise the apoptotic proteins as potential biomarkers and druggable targets of the cancers by effectively killing cancer stem cells.

肿瘤干细胞的凋亡开关:一种潜在的癌症治疗方法。
目前,癌症疾病占全球死亡人数的15%左右,未来这一比例可能会增加。癌症有100多种,每一种癌症的起源、微环境、生长、转移和信号通路都是不同的。癌症干细胞是一种特殊的细胞,它使癌症更具攻击性,更难治疗。此外,癌症病因可能存在于基因组、蛋白质组学或栖息地水平的任何组合。因此,针对不同的癌症制定一致的治疗方案在目前是一项艰巨的任务。在这种背景下,本综述旨在对抗凋亡蛋白进行全面的重新评估,这些抗凋亡蛋白在大多数癌症中被证明是过表达的,如果不是全部的话,并且通过有效杀死癌症干细胞,直接使凋亡蛋白作为癌症的潜在生物标志物和药物靶点变得合理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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