Sergio Machado, João Lucas Lima, Claudio Imperatori, Alberto Souza de Sá Filho
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引用次数: 0
Abstract
So far, there is no specific and effective drug for the treatment of autism symptoms, just to comorbidities associated with ASD.2 A few years ago, some studies investigated the effects of a specific drug, called bumetanide on autism symptoms in children and adults.3-5 Bumetanide is an inhibitor of the Na+–K+–2Cl− cotransporter 1 (NKCC1) that plays essential roles in GABA receptors.6 Evidence has shown that dysfunction in the GABAergic signaling pathway is significantly associated with the main symptoms of ASD.7
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