Trispecific antibodies for cancer immunotherapy

IF 4.9 3区医学 Q2 IMMUNOLOGY

Immunology Pub Date : 2023-03-01 DOI:10.1111/imm.13636

Yin Yao, Yiyin Hu, Fei Wang

引用次数: 1

Abstract

Despite the clinical success of monoclonal and bispecific antibodies, there are still limitations in the therapeutic effect of malignant tumours, such as low response rate, treatment resistance, and so on, inspiring the exploration of trispecific antibodies (TsAbs). TsAbs further improve the safety and efficacy and has great clinical potential through three targets combination and formats optimization. This article reviews the development history and the target combination features of TsAbs. Although there are still great challenges in the clinical application of TsAbs, it is undeniable that TsAbs may be a breakthrough in the development of antibody drugs.

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癌症免疫治疗的三特异性抗体

尽管单克隆抗体和双特异性抗体在临床上取得了成功，但恶性肿瘤的治疗效果仍然存在局限性，如反应率低、治疗耐药性等，这激发了对三特异性抗体（TsAbs）的探索。TsAbs通过三靶点组合和格式优化，进一步提高了安全性和有效性，具有巨大的临床潜力。本文回顾了TsAbs的发展历史和目标组合特征。尽管TsAbs的临床应用仍存在巨大挑战，但不可否认的是，TsAbs可能是抗体药物开发的一个突破。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunology 医学-免疫学

CiteScore

11.90

自引率

1.60%

发文量

175

审稿时长

4-8 weeks

期刊介绍： Immunology is one of the longest-established immunology journals and is recognised as one of the leading journals in its field. We have global representation in authors, editors and reviewers. Immunology publishes papers describing original findings in all areas of cellular and molecular immunology. High-quality original articles describing mechanistic insights into fundamental aspects of the immune system are welcome. Topics of interest to the journal include: immune cell development, cancer immunology, systems immunology/omics and informatics, inflammation, immunometabolism, immunology of infection, microbiota and immunity, mucosal immunology, and neuroimmunology. The journal also publishes commissioned review articles on subjects of topical interest to immunologists, and commissions in-depth review series: themed sets of review articles which take a 360° view of select topics at the heart of immunological research.