Role of (F-18) Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Prediction of Response to Neoadjuvant Therapy in Esophageal Cancer: Correlation with Pathological Response and Survival.

IF 0.4 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Indian Journal of Nuclear Medicine Pub Date : 2023-04-01 Epub Date: 2023-06-08 DOI:10.4103/ijnm.ijnm_12_22
Javier J Robles Barba, Aida Sabaté Llobera, Cristina Gámez Cenzano, Juan J Martin Marcuartu, Natalia Romero Martínez, Maria J Paules Villar, Carla Bettonica Larrañaga, Anna Boladeras Inglada, Mariona Calvo Campos, Albert Font Pous, Maica Galán Guzmán, Montserrat Cortés Romera
{"title":"Role of (F-18) Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Prediction of Response to Neoadjuvant Therapy in Esophageal Cancer: Correlation with Pathological Response and Survival.","authors":"Javier J Robles Barba,&nbsp;Aida Sabaté Llobera,&nbsp;Cristina Gámez Cenzano,&nbsp;Juan J Martin Marcuartu,&nbsp;Natalia Romero Martínez,&nbsp;Maria J Paules Villar,&nbsp;Carla Bettonica Larrañaga,&nbsp;Anna Boladeras Inglada,&nbsp;Mariona Calvo Campos,&nbsp;Albert Font Pous,&nbsp;Maica Galán Guzmán,&nbsp;Montserrat Cortés Romera","doi":"10.4103/ijnm.ijnm_12_22","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study is to assess the correlation between metabolic response with fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) and pathological response in patients with locally advanced esophageal cancer treated with neoadjuvant chemoradiotherapy and to study FDG-PET parameters for the prediction of pathological response and outcome.</p><p><strong>Methods: </strong>Twenty-five patients with locally advanced esophageal cancer underwent two FDG-PET/CT scans for initial staging and after neoadjuvant chemoradiotherapy. FDG uptake in the primary tumor was calculated in both scans (SUVmax, SULpeak, and TLG). Metabolic response was assessed according to the reduction of PET parameters: complete response (mCR = 100%), partial response (mPR ≥50%), and no response (mNR ≤50%). Pathological response was also classified as complete (pCR), partial (pPR), or no response (pNR). Patients were followed up (range, 8-99 months) determining free-disease interval (FDI) and overall survival (OS).</p><p><strong>Results: </strong>Two patients were excluded due to exitus for nonesophageal-related causes. The metabolic response was observed in 18/23 remaining patients (3mCR, 15 mPR), of which 12/18 patients showed a pathological response (3 pCR, 9 pPR). A major discrepancy was observed in 2 mNR patients who achieved pPR. FDI and OS were longer in patients with metabolic response than nonresponders, but no statistical difference was found. No significant correlation was found between PET parameters and pathological response, FDI, and OS.</p><p><strong>Conclusions: </strong>FDG-PET/CT is a useful technique to assess response to neoadjuvant chemoradiotherapy in esophageal cancer. Although in this preliminary study, no correlation between metabolic and pathologic response was found and no statistical differences between responders and nonresponders were observed, a tendency of longer FDI and OS was apparently found in responders patients.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"38 2","pages":"97-102"},"PeriodicalIF":0.4000,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/12/bb/IJNM-38-97.PMC10348503.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Nuclear Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ijnm.ijnm_12_22","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/6/8 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0

Abstract

Purpose: The purpose of this study is to assess the correlation between metabolic response with fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) and pathological response in patients with locally advanced esophageal cancer treated with neoadjuvant chemoradiotherapy and to study FDG-PET parameters for the prediction of pathological response and outcome.

Methods: Twenty-five patients with locally advanced esophageal cancer underwent two FDG-PET/CT scans for initial staging and after neoadjuvant chemoradiotherapy. FDG uptake in the primary tumor was calculated in both scans (SUVmax, SULpeak, and TLG). Metabolic response was assessed according to the reduction of PET parameters: complete response (mCR = 100%), partial response (mPR ≥50%), and no response (mNR ≤50%). Pathological response was also classified as complete (pCR), partial (pPR), or no response (pNR). Patients were followed up (range, 8-99 months) determining free-disease interval (FDI) and overall survival (OS).

Results: Two patients were excluded due to exitus for nonesophageal-related causes. The metabolic response was observed in 18/23 remaining patients (3mCR, 15 mPR), of which 12/18 patients showed a pathological response (3 pCR, 9 pPR). A major discrepancy was observed in 2 mNR patients who achieved pPR. FDI and OS were longer in patients with metabolic response than nonresponders, but no statistical difference was found. No significant correlation was found between PET parameters and pathological response, FDI, and OS.

Conclusions: FDG-PET/CT is a useful technique to assess response to neoadjuvant chemoradiotherapy in esophageal cancer. Although in this preliminary study, no correlation between metabolic and pathologic response was found and no statistical differences between responders and nonresponders were observed, a tendency of longer FDI and OS was apparently found in responders patients.

Abstract Image

Abstract Image

Abstract Image

(F-18)氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描在预测癌症新辅助治疗反应中的作用:与病理反应和生存率的相关性。
目的:本研究旨在评估氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描(FDG-PET/CT)代谢反应与局部晚期食管癌症新辅助放化疗患者病理反应之间的相关性,并研究FDG-PET参数用于预测病理反应和结果。方法:对20例局部晚期食管癌症患者进行FDG-PET/CT两次扫描,初步分期和新辅助放化疗后。在两次扫描中计算原发性肿瘤中的FDG摄取(SUVmax、SULpeak和TLG)。根据PET参数的减少来评估代谢反应:完全反应(mCR=100%)、部分反应(mPR≥50%)和无反应(mNR≤50%)。病理反应也分为完全反应(pCR)、部分反应(pPR)或无反应(pNR)。对患者进行随访(范围为8-99个月),确定无病间期(FDI)和总生存期(OS)。结果:两名患者因非食道相关原因而被排除在外。在剩下的18/23名患者中观察到代谢反应(3mCR,15mPR),其中12/18名患者表现出病理反应(3pCR,9pPR)。在达到pPR的2mNR患者中观察到一个主要差异。有代谢反应的患者的FDI和OS比无反应的患者长,但没有发现统计学差异。PET参数与病理反应、FDI和OS之间无显著相关性。结论:FDG-PET/CT是评估癌症新辅助放化疗疗效的有效技术。尽管在这项初步研究中,没有发现代谢和病理反应之间的相关性,也没有观察到应答者和无应答者之间的统计差异,但在应答患者中明显发现了更长的FDI和OS的趋势。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Indian Journal of Nuclear Medicine
Indian Journal of Nuclear Medicine RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
0.70
自引率
0.00%
发文量
46
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信