Sofia Klavebäck, Helga Skúladóttir, Joakim Olbers, Jan Östergren, Frieder Braunschweig
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引用次数: 0
Abstract
Objectives: Symptoms in atrial fibrillation (AF) range from none to disabling. The physiological correlates of AF symptoms are not well characterized. This study investigated the association between physiological parameters and symptom severity before and after electrical cardioversion (EC) of AF.
Design: We studied 44 patients with persistent AF (age 66.2 ± 7.9 years, 16% females) 4 ± 2 days before and 5 ± 2 days after EC. Physiological parameters included cardiac output (CO; non-invasive inert gas rebreathing), heart rate (HR), RR variability and resting and ambulatory blood pressure (BP). Symptoms and quality of life (QoL) were assessed by the modified European Heart Rhythm Association score (mEHRA), the Atrial Fibrillation Effect on Quality of Life (AFEQT) and the Symptom Checklist for frequency and severity of symptoms (SCL).
Results: 28 of 44 patients were still in sinus rhythm (SR) at post EC evaluation. Those in SR had a decreased HR (-15.4 ± 13.1 bpm, p < 0.001), and an increased CO (+0.8 ± 0.7 L/min, p < 0.001) as compared to those with recurrent AF. Changes in CO after EC correlated with symptom improvement as scored by AFEQT (r = 0.36; p < 0.05), AFEQT symptoms subscore (r = 0.46; p < 0.01), SCL for frequency (r = 0.62; p < 0.01) and severity (r = 0.33; p < 0.05) of symptoms, and the mEHRA score (r = 0.50; p < 0.01). A decrease in RR variability showed similar correlations with these measures of symptom improvement.
Conclusions: Improvements in symptoms and quality of life experienced by patients after electrical conversion of atrial fibrillation are correlated with an increase in CO and a decreased RR variability.
目的：心房颤动（AF）的症状从无症状到致残不等。房颤症状的生理相关性尚未得到很好的表征。本研究调查了房颤电复律前后生理参数与症状严重程度之间的关系。设计：我们研究了44例持续性房颤患者（年龄66.2岁） ± 7.9 年龄，16%女性）4 ± 2. 前几天和第5天 ± 2. 生理参数包括心输出量（CO；无创惰性气体再呼吸）、心率（HR）、RR变异性以及静息和动态血压（BP）。采用改良的欧洲心律协会评分（mEHRA）、心房颤动对生活质量的影响（AFEQT）和症状频率和严重程度症状自评量表（SCL）评估症状和生活质量（QoL）。SR患者的HR降低（-15.4 ± 13.1 bpm，p p r = 0.36；p r = 0.46；p r = 0.62；p r = 0.33；p r = 0.50；p 结论：心房颤动电转换后患者症状和生活质量的改善与CO的增加和RR变异性的降低有关。
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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