Histamine-producing bacteria and their role in gastrointestinal disorders.

IF 3.8 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Marcello Fiorani, Livio Enrico Del Vecchio, Pasquale Dargenio, Francesco Kaitsas, Tommaso Rozera, Serena Porcari, Antonio Gasbarrini, Giovanni Cammarota, Gianluca Ianiro
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引用次数: 0

Abstract

Introduction: Gut microbiota produces thousands of metabolites, which have a huge impact on the host health. Specific microbial strains are able to synthesize histamine, a molecule with a crucial role in many physiologic and pathologic mechanisms of the host. This function is mediated by the histidine decarboxylase enzyme (HDC) that converts the amino acid histidine to histamine.

Areas covered: This review summarizes the emerging data on histamine production by gut microbiota, and the effect of bacterial-derived histamine in different clinical contexts, including cancer, irritable bowel syndrome, and other gastrointestinal and extraintestinal pathologies. This review will also outline the impact of histamine on the immune system and the effect of probiotics that can secrete histamine. Search methodology: we searched the literature on PubMed up to February 2023.

Expert opinion: The potential of modulating gut microbiota to influence histamine production is a promising area of research, and although our knowledge of histamine-secreting bacteria is still limited, recent advances are exploring their diagnostic and therapeutical potential. Diet, probiotics, and pharmacological treatments directed to the modulation of histamine-secreting bacteria may in the future potentially be employed in the prevention and management of several gastrointestinal and extraintestinal disorders.

组胺产生菌及其在胃肠道疾病中的作用。
引言:肠道微生物群产生数千种代谢产物,对宿主健康有巨大影响。特定的微生物菌株能够合成组胺,组胺是一种在宿主的许多生理和病理机制中发挥关键作用的分子。这种功能是由组氨酸脱羧酶(HDC)介导的,该酶将氨基酸组氨酸转化为组胺。涵盖的领域:本综述总结了肠道微生物群产生组胺的新数据,以及细菌来源的组胺在不同临床背景下的影响,包括癌症、肠易激综合征和其他胃肠道和肠外病理。这篇综述还将概述组胺对免疫系统的影响以及可以分泌组胺的益生菌的作用。搜索方法:我们在PubMed上搜索了截至2023年2月的文献。专家意见:调节肠道微生物群影响组胺产生的潜力是一个很有前途的研究领域,尽管我们对组胺分泌细菌的了解仍然有限,但最近的进展正在探索其诊断和治疗潜力。针对组胺分泌细菌的饮食、益生菌和药理学治疗可能在未来用于预防和治疗几种胃肠道和肠外疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Expert Review of Gastroenterology & Hepatology
Expert Review of Gastroenterology & Hepatology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
6.80
自引率
2.60%
发文量
86
审稿时长
6-12 weeks
期刊介绍: The enormous health and economic burden of gastrointestinal disease worldwide warrants a sharp focus on the etiology, epidemiology, prevention, diagnosis, treatment and development of new therapies. By the end of the last century we had seen enormous advances, both in technologies to visualize disease and in curative therapies in areas such as gastric ulcer, with the advent first of the H2-antagonists and then the proton pump inhibitors - clear examples of how advances in medicine can massively benefit the patient. Nevertheless, specialists face ongoing challenges from a wide array of diseases of diverse etiology.
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