Role of mitochondria in regulating immune response during bacterial infection.

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Shaziya Khan, Swarnali Basu, Desh Raj, Amit Lahiri
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引用次数: 3

Abstract

Mitochondria are dynamic organelles of eukaryotes involved in energy production and fatty acid oxidation. Besides maintaining ATP production, calcium signaling, cellular apoptosis, and fatty acid synthesis, mitochondria are also known as the central hub of the immune system as it regulates the innate immune pathway during infection. Mitochondria mediated immune functions mainly involve regulation of reactive oxygen species production, inflammasome activation, cytokine secretion, and apoptosis of infected cells. Recent findings indicate that cellular mitochondria undergo constant biogenesis, fission, fusion and degradation, and these dynamics regulate cellular immuno-metabolism. Several intracellular pathogens target and modulate these normal functions of mitochondria to facilitate their own survival and growth. De-regulation of mitochondrial functions and dynamics favors bacterial infection and pathogens are able to protect themselves from mitochondria mediated immune responses. Here, we will discuss how mitochondria mediated anti-bacterial immune pathways help the host to evade pathogenic insult. In addition, examples of bacterial pathogens modulating mitochondrial metabolism and dynamics will also be elaborated. Study of these interactions between the mitochondria and bacterial pathogens during infection will lead to a better understanding of the mitochondrial metabolism pathways and dynamics important for the establishment of bacterial diseases. In conclusion, detailed studies on how mitochondria regulate the immune response during bacterial infection can open up new avenues to develop mitochondria centric anti-bacterial therapeutics.

线粒体在细菌感染期间调节免疫反应中的作用。
线粒体是真核生物参与能量产生和脂肪酸氧化的动态细胞器。除了维持ATP的产生、钙信号传导、细胞凋亡和脂肪酸合成外,线粒体还被认为是免疫系统的中枢,因为它在感染期间调节先天免疫途径。线粒体介导的免疫功能主要涉及活性氧产生、炎性体激活、细胞因子分泌和感染细胞凋亡的调节。最近的研究表明,细胞线粒体经历了不断的生物发生、裂变、融合和降解,这些动态调节着细胞的免疫代谢。一些细胞内病原体靶向并调节线粒体的这些正常功能,以促进自身的生存和生长。线粒体功能和动力学的去调控有利于细菌感染和病原体能够保护自己免受线粒体介导的免疫反应。在这里,我们将讨论线粒体介导的抗菌免疫途径如何帮助宿主逃避病原性损伤。此外,细菌病原体调节线粒体代谢和动力学的例子也将被详细阐述。研究感染过程中线粒体和细菌病原体之间的相互作用将有助于更好地理解线粒体代谢途径和动力学,这对细菌疾病的建立至关重要。总之,对细菌感染过程中线粒体如何调节免疫反应的详细研究可以为开发以线粒体为中心的抗菌药物开辟新的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International review of cell and molecular biology
International review of cell and molecular biology BIOCHEMISTRY & MOLECULAR BIOLOGY-CELL BIOLOGY
CiteScore
7.70
自引率
0.00%
发文量
67
审稿时长
>12 weeks
期刊介绍: International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
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