Relationship of digit ratio with sexual steroid hormone receptor related genes - single nucleotide polymorphisms in a sample from Northern China.

IF 1.2 4区医学 Q2 ANTHROPOLOGY

Annals of Human Biology Pub Date : 2023-02-01 DOI:10.1080/03014460.2023.2225873

Jie Dang, Chengfeng Ma, Fan Li, Jing Zhang, Yuan Wang, Liang Peng, Zhenghao Huo, Hong Lu, Zhanbing Ma

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引用次数: 0

Abstract

Background: Digit ratio, especially 2D:4D, is hypothesised as a potential biological marker of exposure to intrauterine sex hormones. The aim of this study was to investigate the association between 10 SNPs of sex steroid hormone receptor (SSHR) related genes and 2D:4D.

Subjects and methods: 814 college students were randomly selected as research participants. After taking pictures of both hands of the participants, Image Pro Plus (IPP) software was used to measure 2D:4D. ESR1 (rs2228480 and rs3798758), ESR2 (rs944459, rs8006145, rs928554, and rs8018687), GPER1 (rs10269151 and rs12702047), and PGR (rs1042839 and rs500760) were genotyped using multiplex PCR.

Results: Females had significantly higher 2D:4D in both hands than male students (p < 0.05), and the R_2D:4D of the Han population was significantly higher than that of the Hui population (p < 0.05). The number of females carrying the GPER1 G allele of rs12702047 was significantly higher than that of males (p < 0.05). The L_2D:4D in males was significantly different in rs1042839, and the R_2D:4D in the Han ethnicity was significantly different in rs3798758. Logistic regression analysis showed that rs12702047 was significantly associated with 2D:4D in both hands (p < 0.05).

Conclusions: GPER1 rs12702047 may be involved in the formation of digit ratio by affecting phalanx development in the Chinese population.

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手指比例与中国北方地区性类固醇激素受体相关基因的关系——单核苷酸多态性。

背景:手指比例，特别是2D:4D，被假设为子宫内性激素暴露的潜在生物学标记。本研究旨在探讨性类固醇激素受体(SSHR)相关基因的10个snp与2D:4D的关系。研究对象与方法:随机选取814名大学生作为研究对象。在拍摄参与者的双手后，使用Image Pro Plus (IPP)软件测量2D:4D。采用多重PCR对ESR1 (rs2228480和rs3798758)、ESR2 (rs944459、rs8006145、rs928554和rs8018687)、GPER1 (rs10269151和rs12702047)和PGR (rs1042839和rs500760)进行基因分型。结果:女生双手2D:4D显著高于男生(汉族群体的2D:4D显著高于回族群体(男性群体的2D:4D在rs1042839中差异显著，汉族群体的R2D:4D在rs3798758中差异显著)。Logistic回归分析显示，rs12702047基因与双手2D:4D显著相关(p)。结论:GPER1 rs12702047基因可能通过影响中国人群指骨发育参与指骨比例的形成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Human Biology 生物-公共卫生、环境卫生与职业卫生

CiteScore

3.40

自引率

5.90%

发文量

审稿时长

1 months

期刊介绍： Annals of Human Biology is an international, peer-reviewed journal published six times a year in electronic format. The journal reports investigations on the nature, development and causes of human variation, embracing the disciplines of human growth and development, human genetics, physical and biological anthropology, demography, environmental physiology, ecology, epidemiology and global health and ageing research.