Systemic inflammation in xenograft recipients (SIXR) or undetected PCMV/PRV transmission?

IF 3.3 4区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Xenotransplantation Pub Date : 2023-01-01 DOI:10.1111/xen.12788

Joachim Denner

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引用次数: 1

Abstract

Transplantation of pig organs into non-human primates has often been associated with clinical symptoms described as systemic inflammation in xenograft recipients (SIXR). 1–4 Systemic inflammation precedes andpromotesactivationofcoagulationafterpig-to-nonhumanprimate xenotransplantation, irrespective of immunosuppressive therapy. 3 Inflammation can be described as a complex biological response of an organism to harmful stimuli and chronic inflammation is observed in various diseases, for example, diabetes, infection, or atherosclerosis. 4 Inflammationisassociatedwiththereleaseofawiderangeofcytokines and chemokines, recruiting immune cells to the site of inflammation and modulating the maturation of immune cells. Among these molecules are tumor necrosis factor (TNF) and interleukin 6 (IL-6), which are highly elevated in animals with SIXR. 5 Innate immune cells expressing tissue factor (TF) are activated after xenotransplantation and expression of the TF by activated endothelial cells is an initial mechanism in the development of thrombotic microangiopathy in the transplant and consumptive coagulopathy (CC) in the recipient. 3,6 Thrombotic microangiopathy and CC are characteristic features asso-ciatedwithxenotransplantfailure. 7,8 TNF-alpha 9 andIL-6 10

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异种移植受者的全身性炎症(SIXR)或未检测到的PCMV/PRV传播?

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来源期刊

Xenotransplantation 医学-医学：研究与实验

CiteScore

6.80

自引率

15.40%

发文量

审稿时长

>12 weeks

期刊介绍： Xenotransplantation provides its readership with rapid communication of new findings in the field of organ and tissue transplantation across species barriers.The journal is not only of interest to those whose primary area is xenotransplantation, but also to veterinarians, microbiologists and geneticists. It also investigates and reports on the controversial theological, ethical, legal and psychological implications of xenotransplantation.