Proposed morbidity markers among Schistosoma mansoni patients.

Q3 Medicine

Tropical Parasitology Pub Date : 2023-01-01 Epub Date: 2023-05-19 DOI:10.4103/tp.tp_46_22

Amel Youssef Shehab, Amal Farahat Allam, Awad Abd El Kader Saad, Mervat Mostafa Osman, Heba Said Ibrahim, Esraa Abdelhamid Moneer, Mona Mohamed Tolba

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引用次数: 0

Abstract

Background: Fecal calprotectin (FC) and fecal occult blood (FOB) were suggested as potential inflammatory markers for assessing intestinal schistosomiasis morbidity that are conventionally detected through invasive methods.

Aim and objectives: The present work aimed to evaluate FC and FOB as morbidity markers of Schistosoma mansoni infection before and after praziquantel treatment.

Materials and methods: A total of 205 stool samples (117 schoolchildren and 88 adults) were collected and examined by Kato Katz. A questionnaire enquiring about diarrhea, history of blood in stool, and abdominal pain was designed and applied.

Results: S. mansoni prevalence rates were 20.5% and 11.36% among children and adults, respectively; the majority of cases had light infection intensity. FC and FOB were studied among 25 cured S. mansoni cases (17 children and 8 adults) pre and one-month post treatment. Before treatment, six and four children of moderate and high S. mansoni infection intensity tested positive for FC and FOB, respectively, all turning negative after treatment. FC showed borderline statistical significance before and after treatment among children. However, all adults tested negative for FC and FOB.

Conclusion: FC and FOB could be possibly used as morbidity monitoring tools for S. mansoni infection in children with moderate and high infection intensity.

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曼氏血吸虫病患者的拟议发病率标志物。

背景：粪便钙卫蛋白（FC）和粪便潜血（FOB）被认为是评估肠道血吸虫病发病率的潜在炎症标志物，这些标志物通常通过侵入性方法检测。目的和目的：本工作旨在评估FC和FOB作为吡喹酮治疗前后曼氏血吸虫感染的发病标志物。材料和方法：Kato Katz收集了205份粪便样本（117名学童和88名成年人）并进行了检查。设计并应用了一份关于腹泻、便血史和腹痛的问卷。结果：儿童和成人曼氏血吸虫病患病率分别为20.5%和11.36%；大多数病例的感染强度较轻。对25例治愈的曼氏血吸虫病例（17名儿童和8名成人）在治疗前和治疗后1个月进行了FC和FOB的研究。治疗前，6名和4名中度和高度曼氏血吸虫感染强度的儿童FC和FOB检测结果分别呈阳性，治疗后均转为阴性。FC在儿童治疗前后具有临界统计学意义。然而，所有成年人的FC和FOB检测结果均为阴性。结论：FC和FOB可作为中、高感染强度儿童曼氏血吸虫感染的发病监测工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tropical Parasitology Medicine-Infectious Diseases

CiteScore

2.40

自引率

0.00%

发文量

期刊介绍： Tropical Parasitology, a publication of Indian Academy of Tropical Parasitology, is a peer-reviewed online journal with Semiannual print on demand compilation of issues published. The journal’s full text is available online at www.tropicalparasitology.org. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. The journal will cover technical and clinical studies related to health, ethical and social issues in field of parasitology. Articles with clinical interest and implications will be given preference.