Protective effect of Bifidobacterium longum BB536 against nausea caused by pirfenidone in a mouse model of pellagra.

IF 3.1 4区医学 Q2 Agricultural and Biological Sciences

Bioscience of Microbiota, Food and Health Pub Date : 2023-01-01 DOI:10.12938/bmfh.2022-042

Koji Kuronuma, Natsumi Susai, Tomohiro Kuroita, Takeshi Yoshioka, Atsushi Saito, Hirofumi Chiba

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Abstract

Pellagra is caused by abnormal intake and/or use of nicotinic acid and is known in part to be induced by the use of medications such as isoniazid or pirfenidone. We previously investigated atypical phenotypes of pellagra, such as nausea, using a mouse model of pellagra and found that gut microbiota play an important role in the development of these phenotypes. Here, we investigated the effect of Bifidobacterium longum BB536 on pellagra-related nausea caused by pirfenidone in our mouse model. Our pharmacological data indicated that pirfenidone (PFD) causes modulation of the gut microbiota profile, which appeared to play an important role in the development of pellagra-related nausea. A gut microbiota-mediated protective effect of B. longum BB536 against nausea caused by PFD was also identified. Finally, the urinary ratio of nicotinamide/N-methylnicotinamide was shown to be a biomarker of pellagra-like adverse effects induced by PFD, and it may contribute to the prevention of these effects in patients with idiopathic pulmonary fibrosis.

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长双歧杆菌BB536对吡非尼酮所致小鼠糙皮病模型恶心的保护作用。

糙皮病是由异常摄入和/或使用烟酸引起的，已知部分是由异烟肼或吡非尼酮等药物引起的。我们之前使用小鼠糙皮病模型研究了糙皮病的非典型表型，如恶心，并发现肠道微生物群在这些表型的发展中起重要作用。在此，我们在小鼠模型中研究了长双歧杆菌BB536对吡非尼酮引起的糙皮相关恶心的影响。我们的药理学数据表明，吡非尼酮(PFD)引起肠道微生物群的调节，这似乎在皮糙皮相关恶心的发展中起重要作用。长芽孢杆菌BB536对PFD引起的恶心也有肠道微生物介导的保护作用。最后，尿中烟酰胺/ n -甲基烟酰胺的比例被证明是PFD诱导的皮糙皮样不良反应的生物标志物，它可能有助于预防特发性肺纤维化患者的这些不良反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioscience of Microbiota, Food and Health Immunology and Microbiology-Applied Microbiology and Biotechnology

CiteScore

5.50

自引率

3.20%

发文量

期刊介绍： Bioscience of Microbiota, Food and Health (BMFH) is a peer-reviewed scientific journal with a specific area of focus: intestinal microbiota of human and animals, lactic acid bacteria (LAB) and food immunology and food function. BMFH contains Full papers, Notes, Reviews and Letters to the editor in all areas dealing with intestinal microbiota, LAB and food immunology and food function. BMFH takes a multidisciplinary approach and focuses on a broad spectrum of issues.