Preoperative Risk Factors in Patients With Pancreatic Cancer.

Naomi Kusama, Yuta Mitobe, Natsuko Hyodo, Tetsuya Miyashita, Yasuko Baba, Takuya Hashimoto, Yoshimi Inagaki
{"title":"Preoperative Risk Factors in Patients With Pancreatic Cancer.","authors":"Naomi Kusama,&nbsp;Yuta Mitobe,&nbsp;Natsuko Hyodo,&nbsp;Tetsuya Miyashita,&nbsp;Yasuko Baba,&nbsp;Takuya Hashimoto,&nbsp;Yoshimi Inagaki","doi":"10.14740/jocmr4906","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Pancreatic cancer is gastrointestinal cancer with a poor prognosis. Although surgical techniques and chemotherapy have improved treatment outcomes, the 5-year survival rate for pancreatic cancer is less than 10%. In addition, resection of pancreatic cancer is highly invasive and is associated with high rates of postoperative complications and hospital mortality. The Japanese Pancreatic Association states that preoperative body composition assessment may predict postoperative complications. However, although impaired physical function is also a risk factor, few studies have examined it in combination with body composition. We examined preoperative nutritional status and physical function as risk factors for postoperative complications in pancreatic cancer patients.</p><p><strong>Methods: </strong>Fifty-nine patients with pancreatic cancer who underwent surgical treatment and were discharged alive from January 1, 2018, to March 31, 2021, at the Japanese Red Cross Medical Center. This retrospective study was conducted using electronic medical records and a database of departments. Body composition and physical function were evaluated before and after surgery, and the risk factors between patients with and without complications were compared.</p><p><strong>Results: </strong>Fifty-nine patients were analyzed: 14 and 45 patients in the uncomplicated and complicated groups, respectively. The major complications were pancreatic fistulas (33%) and infections (22%). There were significant differences in: age, 74.0 (44 - 88) (P = 0.02); walking speed, 0.93 m/s (0.3 - 2.2) (P = 0.01); and fat mass, 16.50 kg (4.7 - 46.2) (P = 0.02), in the patients with complications. On Multivariable logistic regression analysis, age (odds ratio: 2.28; confidence interval (CI): 1.3400 - 569.00; P = 0.03), preoperative fat mass (odds ratio: 2.28; CI: 1.4900 - 168.00; P = 0.02), and walking speed (odds ratio: 0.119; CI: 0.0134 - 1.07; P = 0.05) were identified as risk factors. Walking speed (odds ratio: 0.119; CI: 0.0134 - 1.07; P = 0.05) was the risk factor that was extracted.</p><p><strong>Conclusions: </strong>Older age, more preoperative fat mass, and decreased walking speed were possible risk factors for postoperative complications.</p>","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":"15 6","pages":"300-309"},"PeriodicalIF":0.0000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0e/42/jocmr-15-300.PMC10332881.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Medicine Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14740/jocmr4906","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Pancreatic cancer is gastrointestinal cancer with a poor prognosis. Although surgical techniques and chemotherapy have improved treatment outcomes, the 5-year survival rate for pancreatic cancer is less than 10%. In addition, resection of pancreatic cancer is highly invasive and is associated with high rates of postoperative complications and hospital mortality. The Japanese Pancreatic Association states that preoperative body composition assessment may predict postoperative complications. However, although impaired physical function is also a risk factor, few studies have examined it in combination with body composition. We examined preoperative nutritional status and physical function as risk factors for postoperative complications in pancreatic cancer patients.

Methods: Fifty-nine patients with pancreatic cancer who underwent surgical treatment and were discharged alive from January 1, 2018, to March 31, 2021, at the Japanese Red Cross Medical Center. This retrospective study was conducted using electronic medical records and a database of departments. Body composition and physical function were evaluated before and after surgery, and the risk factors between patients with and without complications were compared.

Results: Fifty-nine patients were analyzed: 14 and 45 patients in the uncomplicated and complicated groups, respectively. The major complications were pancreatic fistulas (33%) and infections (22%). There were significant differences in: age, 74.0 (44 - 88) (P = 0.02); walking speed, 0.93 m/s (0.3 - 2.2) (P = 0.01); and fat mass, 16.50 kg (4.7 - 46.2) (P = 0.02), in the patients with complications. On Multivariable logistic regression analysis, age (odds ratio: 2.28; confidence interval (CI): 1.3400 - 569.00; P = 0.03), preoperative fat mass (odds ratio: 2.28; CI: 1.4900 - 168.00; P = 0.02), and walking speed (odds ratio: 0.119; CI: 0.0134 - 1.07; P = 0.05) were identified as risk factors. Walking speed (odds ratio: 0.119; CI: 0.0134 - 1.07; P = 0.05) was the risk factor that was extracted.

Conclusions: Older age, more preoperative fat mass, and decreased walking speed were possible risk factors for postoperative complications.

Abstract Image

Abstract Image

Abstract Image

胰腺癌患者术前危险因素分析。
背景:胰腺癌是一种预后较差的胃肠道肿瘤。虽然手术技术和化疗改善了治疗效果,但胰腺癌的5年生存率不到10%。此外,胰腺癌切除术是高度侵入性的,与术后并发症和住院死亡率高相关。日本胰腺协会指出,术前身体成分评估可以预测术后并发症。然而,尽管身体机能受损也是一个风险因素,但很少有研究将其与身体成分结合起来进行研究。我们研究了胰腺癌患者术前营养状况和身体功能作为术后并发症的危险因素。方法:2018年1月1日至2021年3月31日在日本红十字会医疗中心接受手术治疗并存活出院的59例胰腺癌患者。本研究采用电子病历和科室数据库进行回顾性研究。评估手术前后的身体成分和身体功能,比较有无并发症患者的危险因素。结果:共分析59例患者,无并发症组14例,并发症组45例。主要并发症为胰瘘(33%)和感染(22%)。年龄为74.0(44 ~ 88岁),差异有统计学意义(P = 0.02);步行速度:0.93 m/s (0.3 ~ 2.2) (P = 0.01);并发症患者脂肪质量16.50 kg (4.7 ~ 46.2) (P = 0.02)。多变量logistic回归分析,年龄(优势比:2.28;置信区间(CI): 1.3400 - 569.00;P = 0.03),术前脂肪量(优势比:2.28;Ci: 1.4900 - 168.00;P = 0.02)、步行速度(优势比:0.119;Ci: 0.0134 - 1.07;P = 0.05)为危险因素。步行速度(优势比:0.119;Ci: 0.0134 - 1.07;P = 0.05)为提取的危险因素。结论:年龄较大、术前脂肪量较大、行走速度减慢是术后并发症的可能危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信