Menstrual cycle influences on cue-induced smoking cravings and heart rate variability.

IF 1.6 4区 心理学 Q3 BEHAVIORAL SCIENCES
Ashley Ethier, Laurie Sykes Tottenham, Jyotpal Singh, J Patrick Neary, Jaroslaw Piskorski, Jennifer L Gordon
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Abstract

Women experience greater difficulties in quitting smoking than men, though the hormonal factors contributing to this sex difference remain to be clarified. The current study aimed to examine menstrual cycle effects on smoking cue-induced cravings as well as examine dynamic reproductive hormone change as a potential mediator underlying any cycle effects observed. Twenty-one women who smoke underwent two laboratory sessions - one in the mid-follicular phase and the other in the late luteal phase - involving an in-vivo smoking cue task, administered before and after exposure to a psychosocial laboratory stressor. Heart rate variability (HRV) and subjective smoking cravings were assessed in response to the cue task. The degree of change in the urinary metabolites of estradiol and progesterone from 2 days before to the day of each laboratory session was measured. Results revealed that both before and following exposure to psychosocial stress, highly nicotine-dependent women exhibited smaller cue-induced increases in HRV relative to the follicular phase. In contrast, less nicotine-dependent women exhibit an increase in HRV in both menstrual cycle phases. Results furthermore suggest that menstrual cycle effects seen in highly nicotine-dependent women are driven by the decline in estradiol and progesterone occurring in the late luteal phase. Though limited by a small sample size, this study suggests that withdrawal from reproductive hormones in the late luteal phase may alter highly nicotine-dependent women's physiological response to smoking cues, which may reflect greater difficulty resisting temptation. These findings may provide some insight regarding women's greater difficulty in maintaining abstinence after quitting smoking.

月经周期对提示诱导的吸烟渴望和心率变异性的影响。
女性在戒烟方面比男性遇到更大的困难,尽管造成这种性别差异的荷尔蒙因素仍有待澄清。目前的研究旨在研究月经周期对吸烟诱导的渴望的影响,以及动态生殖激素变化作为观察到的任何周期影响的潜在中介。21名吸烟的女性接受了两个实验阶段——一个在卵泡中期,另一个在黄体晚期——包括一个体内吸烟提示任务,在暴露于心理社会实验室压力源之前和之后进行。对提示任务的反应进行心率变异性(HRV)和主观吸烟渴望的评估。测定各组实验前2天至实验当天尿液中雌二醇和黄体酮代谢物的变化程度。结果显示,在暴露于社会心理压力之前和之后,高度尼古丁依赖的女性相对于卵泡期表现出较小的线索诱导的HRV升高。相反,较少依赖尼古丁的女性在两个月经周期阶段都表现出HRV的增加。结果进一步表明,在高度依赖尼古丁的女性中,月经周期的影响是由黄体晚期出现的雌二醇和黄体酮的下降所驱动的。尽管样本量有限,但这项研究表明,在黄体晚期退出生殖激素可能会改变高度依赖尼古丁的女性对吸烟线索的生理反应,这可能反映出更大的抵抗诱惑的困难。这些发现可能为女性在戒烟后保持戒烟的难度更大提供了一些见解。
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来源期刊
Behavioural Pharmacology
Behavioural Pharmacology 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
84
审稿时长
6-12 weeks
期刊介绍: Behavioural Pharmacology accepts original full and short research reports in diverse areas ranging from ethopharmacology to the pharmacology of schedule-controlled operant behaviour, provided that their primary focus is behavioural. Suitable topics include drug, chemical and hormonal effects on behaviour, the neurochemical mechanisms under-lying behaviour, and behavioural methods for the study of drug action. Both animal and human studies are welcome; however, studies reporting neurochemical data should have a predominantly behavioural focus, and human studies should not consist exclusively of clinical trials or case reports. Preference is given to studies that demonstrate and develop the potential of behavioural methods, and to papers reporting findings of direct relevance to clinical problems. Papers making a significant theoretical contribution are particularly welcome and, where possible and merited, space is made available for authors to explore fully the theoretical implications of their findings. Reviews of an area of the literature or at an appropriate stage in the development of an author’s own work are welcome. Commentaries in areas of current interest are also considered for publication, as are Reviews and Commentaries in areas outside behavioural pharmacology, but of importance and interest to behavioural pharmacologists. Behavioural Pharmacology publishes frequent Special Issues on current hot topics. The editors welcome correspondence about whether a paper in preparation might be suitable for inclusion in a Special Issue.
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