The Effect of Standard Compression Adjuvant with a Tailored Exercise Training Program on Health-Related Quality of Life Outcomes in Treating Adults with Venous Leg Ulcer: A Randomized Controlled Trial.
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引用次数: 0
Abstract
Exercise training adjuvant to standard compression is considered to improve calf muscle pump dysfunction in venous leg ulcer (VLU) and subsequent healing. The objectives of this trial were to assess the effectiveness of a tailored exercise training intervention in addition to standard compression therapy on health-related quality of life and anticipating wound healing. Twenty-four VLU participants were recruited and randomly divided into 2 groups. The control group was prescribed conventional compression, and the intervention group received compression plus progressive tailored exercise training. The 14-item chronic venous disease quality of life questionnaire (CIVIQ-14) was used to assess improvement after treatment over time (0, 6, and 12 weeks). Intervention and control groups achieved wound closure for 11 (92%) and 7 (58%) patients. After adjusting for age, sex, and wound size at baseline, the exercise intervention group had 2 times the probability of complete wound healing in 12 weeks than those in the control group (risk ratio = 1.98, 95% CI= 1.01-3.72, P = .047). The primary outcome was the difference in CIVIQ-14 score in 3 dimensions and global index score per visit. The outcomes were evaluated by independent assessors. Demographic, comorbidities, and wound assessments were collected on enrollment. The overall adherence to exercise protocol was 71%. After adjusting age, sex, size of VLU, and CIVIQ score at baseline, the participants in the intervention group had the average global index scores and psychological scores increase at week 12 than those in the control group (21.2; 95% CI= 7.1-35.2, P = .005, and 13.5; 95% CI = 2.9-24.2, P = .044, respectively). Both groups showed similar improvement in the mean change in physical and pain scores within-group over time. Patients with combined conventional compression therapy with exercise training appeared to have a higher quality of life score in psychological and global scores than those with compression therapy alone.
运动训练辅助标准压缩被认为可以改善小腿静脉性溃疡（VLU）的小腿肌泵功能障碍和随后的愈合。本试验的目的是评估除了标准压迫治疗外，量身定制的运动训练干预对健康相关生活质量和预测伤口愈合的有效性。24名VLU参与者被招募并随机分为两组。对照组给予常规压缩，干预组给予压缩加渐进式运动训练。采用14项慢性静脉疾病生活质量问卷（CIVIQ-14）来评估治疗后（0、6和12周）的改善情况。干预组和对照组分别有11例（92%）和7例（58%）患者伤口愈合。在调整年龄、性别和基线时创面大小后，运动干预组创面在12周内完全愈合的概率是对照组的2倍（风险比= 1.98,95% CI= 1.01-3.72, P = 0.047）。主要观察指标为3个维度的CIVIQ-14评分和每次就诊的总体指数评分的差异。结果由独立评估人员评估。在入组时收集人口统计、合并症和伤口评估。运动方案的总体依从性为71%。在调整基线年龄、性别、VLU大小和CIVIQ评分后，干预组参与者在第12周的平均整体指数得分和心理得分均高于对照组(21.2;95% CI= 7.1-35.2, P =。005和13.5；95% ci = 2.9-24.2, p =。044年,分别)。随着时间的推移，两组在身体和疼痛评分的平均变化方面都显示出相似的改善。常规压缩疗法与运动训练相结合的患者在心理和整体评分方面似乎比单独压缩疗法的患者有更高的生活质量评分。
期刊介绍：
The International Journal of Lower Extremity Wounds (IJLEW) is a quarterly, peer-reviewed journal publishing original research, reviews of evidence-based diagnostic techniques and methods, disease and patient management, and surgical and medical therapeutics for lower extremity wounds such as burns, stomas, ulcers, fistulas, and traumatic wounds. IJLEW also offers evaluations of assessment and monitoring tools, dressings, gels, cleansers, pressure management, footwear/orthotics, casting, and bioengineered skin. This journal is a member of the Committee on Publication Ethics (COPE).
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