Potential regulatory effects of stem cell exosomes on inflammatory response in ischemic stroke treatment.

IF 3.6 3区医学 Q3 CELL & TISSUE ENGINEERING

World journal of stem cells Pub Date : 2023-06-26 DOI:10.4252/wjsc.v15.i6.561

Na Chen, Yan-Lin Wang, Hui-Fang Sun, Zhuo-Ya Wang, Qi Zhang, Fei-Yan Fan, Yu-Cheng Ma, Fei-Xiang Liu, Yun-Ke Zhang

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引用次数: 1

Abstract

The high incidence and disability rates of stroke pose a heavy burden on society. Inflammation is a significant pathological reaction that occurs after an ischemic stroke. Currently, therapeutic methods, except for intravenous thrombolysis and vascular thrombectomy, have limited time windows. Mesenchymal stem cells (MSCs) can migrate, differentiate, and inhibit inflammatory immune responses. Exosomes (Exos), which are secretory vesicles, have the characteristics of the cells from which they are derived, making them attractive targets for research in recent years. MSC-derived exosomes can attenuate the inflammatory response caused by cerebral stroke by modulating damage-associated molecular patterns. In this review, research on the inflammatory response mechanisms associated with Exos therapy after an ischemic injury is discussed to provide a new approach to clinical treatment.

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干细胞外泌体对缺血性卒中治疗中炎症反应的潜在调节作用。

脑卒中的高发病率和致残率给社会造成了沉重的负担。炎症是缺血性中风后发生的重要病理反应。目前，除静脉溶栓和血管取栓外，其他治疗方法的时间窗有限。间充质干细胞(MSCs)可以迁移、分化和抑制炎症免疫反应。外泌体(Exos)是一种分泌囊泡，具有其来源细胞的特性，使其成为近年来研究的一个有吸引力的目标。骨髓间质干细胞衍生的外泌体可以通过调节损伤相关的分子模式来减轻脑卒中引起的炎症反应。本文就缺血性损伤后Exos治疗相关炎症反应机制的研究进行综述，以期为临床治疗提供新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World journal of stem cells Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

7.80

自引率

4.90%

发文量

750

期刊介绍： The World Journal of Stem Cells (WJSC) is a leading academic journal devoted to reporting the latest, cutting-edge research progress and findings of basic research and clinical practice in the field of stem cells. It was launched on December 31, 2009 and is published monthly (12 issues annually) by BPG, the world''s leading professional clinical medical journal publishing company.