Antimicrobial oral lavage reduces the SARS-CoV-2 load in intubated patients: randomized clinical trial.

IF 3.7 2区医学 Q2 MICROBIOLOGY

Journal of Oral Microbiology Pub Date : 2023-01-01 DOI:10.1080/20002297.2022.2152179

Letícia Mello Bezinelli, Luciana Corrêa, Stephany Beyerstedt, Érika Bevilaqua Rangel, Carlos Benitez, Nelson Hamerschlak, João Renato Rebello Pinho, Debora Heller, Fernanda de Paula Eduardo

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引用次数: 1

Abstract

Background: The oral cavity can be a reservoir for SARS-CoV-2 and may play a crucial role in the viral transmission in the hospital environment.

Objective: To investigate whether an oral hygiene protocol with chlorhexidine (CHX) used alone and in combination with hydrogen peroxide (HP) in the intensive care unit was effective in reducing the SARS-CoV-2 viral load in the oral cavity.

Methods: SARS-CoV-2 viral load was measured on oral fluid samples collected from patients undergoing orotracheal intubation. The study sample was randomly in: CHX group (n = 19) - oral rinse using only 0.12% CHX solution; HP+CHX group (n = 24) - oral rinse with 1.5% HP and 0.12% CHX. The samples were collected before the interventions (T0), immediately (T1), 30 minutes (T2) and 60 minutes (T3) after the procedure.

Results: A significant viral load reduction was observed at T1 (mean ± SD:-0.57 ± 0.19 log10;-73.2%;p = 0.022) in the HP+CHX group. No statistically significant differences between any time points were observed in the CHX group.

Conclusion: The HP+CHX oral rinses significantly reduced the SARS-CoV-2 viral load in the oral fluid immediately after the procedure. The CHX oral rinse alone did not result in any significant viral load reductions.

Abstract Image

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抗菌口腔灌洗可降低插管患者的SARS-CoV-2载量:随机临床试验

背景:口腔可能是SARS-CoV-2的储存库，并可能在医院环境中病毒传播中发挥关键作用。目的:探讨重症监护室单独使用氯己定(CHX)和联合使用双氧水(HP)的口腔卫生方案是否能有效降低口腔内SARS-CoV-2病毒载量。方法:对经口气管插管患者的口腔液样本进行SARS-CoV-2病毒载量测定。研究样本随机分为:CHX组(n = 19) -仅使用0.12% CHX溶液的口腔冲洗液;HP+CHX组(n = 24): 1.5% HP+ 0.12% CHX的口腔冲洗液。样本分别于干预前(T0)、即刻(T1)、干预后30分钟(T2)和60分钟(T3)采集。结果:在T1时，HP+CHX组的病毒载量显著降低(mean±SD:-0.57±0.19 log10;-73.2%;p = 0.022)。CHX组各时间点间无统计学差异。结论:HP+CHX口腔冲洗液可显著降低术后即刻口服液中SARS-CoV-2病毒载量。单独使用CHX口腔冲洗液不能显著降低病毒载量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Oral Microbiology MICROBIOLOGY-

CiteScore

8.00

自引率

4.40%

发文量

审稿时长

12 weeks

期刊介绍： As the first Open Access journal in its field, the Journal of Oral Microbiology aims to be an influential source of knowledge on the aetiological agents behind oral infectious diseases. The journal is an international forum for original research on all aspects of ''oral health''. Articles which seek to understand ''oral health'' through exploration of the pathogenesis, virulence, host-parasite interactions, and immunology of oral infections are of particular interest. However, the journal also welcomes work that addresses the global agenda of oral infectious diseases and articles that present new strategies for treatment and prevention or improvements to existing strategies. Topics: ''oral health'', microbiome, genomics, host-pathogen interactions, oral infections, aetiologic agents, pathogenesis, molecular microbiology systemic diseases, ecology/environmental microbiology, treatment, diagnostics, epidemiology, basic oral microbiology, and taxonomy/systematics. Article types: original articles, notes, review articles, mini-reviews and commentaries