Simultaneous seroprevalence of Toxoplasma gondii and rubella virus infections in pregnant women in Dakar (Senegal).

Q3 Medicine

Tropical Parasitology Pub Date : 2023-01-01 Epub Date: 2023-05-19 DOI:10.4103/tp.tp_29_22

Mame Cheikh Seck, Papa A T Gueye, Pasca E Engo, Cheikh Faye, Moustapha Mbow, Khadim Diongue, Mamadou A Diallo, Mouhamadou Ndiaye, Aida S Badiane, Daouda Ndiaye

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引用次数: 0

Abstract

Context: Toxoplasma gondii and rubella virus are microorganisms that can cause intrauterine infections and congenital anomalies in the fetus. Data regarding the simultaneous seroprevalence of these infections are not available in Senegal.

Aims: This study aimed to determine for the first time the simultaneous seroprevalence of toxoplasmosis and rubella among pregnant women in Dakar.

Materials and methods: In this retrospective study, anti-Toxoplasma and anti-rubella antibodies were analyzed in the serum samples obtained from pregnant women receiving prenatal care at Military Hospital of Ouakam between 2016 and 2021 using a chemiluminescent microparticle immunoassay for the quantitative determination of immunoglobulin G (IgG) and IgM antibodies to Toxoplasma gondii and rubella in human serum.

Results: Overall, data from 2589 women were analyzed. The median age was 29 years (interquartile range: 23.14-34.86). Serum IgG and IgM were positive for T. gondii with 35.84% and 1.66%, respectively. Rubella seroprevalence was 87.14% and 0.35%, respectively, for IgG and IgM. Seroprevalence of toxoplasmosis increases significantly with age and study period. For rubella infection, the highest seroprevalence rates were noted in the youngest age group and at the end of the study period.

Conclusions: Data from this first-time study regarding simultaneous seroprevalence of toxoplasmosis and rubella among pregnant women in Senegal indicate a continuing high risk of congenital toxoplasmosis and congenital rubella syndrome in Dakar. Further studies are needed to fully assess the efficacy of rubella vaccination in women of childbearing age.

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达喀尔（塞内加尔）孕妇弓形虫和风疹病毒感染的同时血清流行率。

背景：弓形虫和风疹病毒是可引起胎儿宫内感染和先天性畸形的微生物。塞内加尔没有关于这些感染同时血清流行率的数据。目的：本研究旨在首次确定达喀尔孕妇中弓形虫病和风疹的同时血清流行。材料和方法：在这项回顾性研究中，使用化学发光微粒免疫测定法对2016年至2021年间在瓦坎军事医院接受产前护理的孕妇的血清样本中的抗弓形虫和抗风疹抗体进行分析，以定量测定人类血清中弓形虫和风疹的免疫球蛋白G（IgG）和IgM抗体。结果：总体而言，对2589名女性的数据进行了分析。中位年龄为29岁（四分位间距：23.14-34.86），弓形虫血清IgG和IgM阳性率分别为35.84%和1.66%。IgG和IgM的风疹血清流行率分别为87.14%和0.35%。弓形虫病的血清患病率随着年龄和研究期的增加而显著增加。对于风疹感染，最年轻的年龄组和研究期结束时的血清流行率最高。结论：这项关于塞内加尔孕妇弓形虫病和风疹同时血清流行率的首次研究的数据表明，达喀尔地区先天性弓形虫症和先天性风疹综合征的风险仍然很高。需要进一步的研究来充分评估风疹疫苗在育龄妇女中的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tropical Parasitology Medicine-Infectious Diseases

CiteScore

2.40

自引率

0.00%

发文量

期刊介绍： Tropical Parasitology, a publication of Indian Academy of Tropical Parasitology, is a peer-reviewed online journal with Semiannual print on demand compilation of issues published. The journal’s full text is available online at www.tropicalparasitology.org. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. The journal will cover technical and clinical studies related to health, ethical and social issues in field of parasitology. Articles with clinical interest and implications will be given preference.