Involvement of miRNA on epigenetics landscape of Parkinson's disease: From pathogenesis to therapeutics

IF 5.3 3区医学 Q2 CELL BIOLOGY

Mechanisms of Ageing and Development Pub Date : 2023-07-01 DOI:10.1016/j.mad.2023.111826

Sai Nikhil Uppala , Kamatham Pushpa Tryphena , Padmashri Naren , Saurabh Srivastava , Shashi Bala Singh , Dharmendra Kumar Khatri

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引用次数: 3

Abstract

The development of novel therapeutics for the effective management of Parkinson’s disease (PD) is undertaken seriously by the scientific community as the burden of PD continues to increase. Several molecular pathways are being explored to identify novel therapeutic targets. Epigenetics is strongly implicated in several neurodegenerative diseases (NDDs) including PD. Several epigenetic mechanisms were found to dysregulated in various studies. These mechanisms are regulated by several miRNAs which are associated with a variety of pathogenic mechanisms in PD. This concept is extensively investigated in several cancers but not well documented in PD. Identifying the miRNAs with dual role i.e., regulation of epigenetic mechanisms as well as modulation of proteins implicated in the pathogenesis of PD could pave way for the development of novel therapeutics to target them. These miRNAs could also serve as potential biomarkers and can be useful in the early diagnosis or assessment of disease severity. In this article we would like to discuss about various epigenetic changes operating in PD and how miRNAs are involved in the regulation of these mechanisms and their potential to be novel therapeutic targets in PD.

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miRNA参与帕金森病的表观遗传学景观:从发病机制到治疗

随着帕金森病负担的不断增加，科学界正在认真开发有效治疗帕金森病的新疗法。目前正在探索几种分子途径来确定新的治疗靶点。表观遗传学与包括帕金森病在内的几种神经退行性疾病密切相关。在各种研究中发现，几种表观遗传学机制失调。这些机制由几种miRNA调节，这些miRNA与帕金森病的各种致病机制有关。这一概念在几种癌症中得到了广泛研究，但在帕金森病中没有得到充分证明。鉴定具有双重作用的miRNA，即。，表观遗传学机制的调节以及参与PD发病机制的蛋白质的调节可能为开发针对它们的新疗法铺平道路。这些miRNA也可以作为潜在的生物标志物，并可用于疾病严重程度的早期诊断或评估。在这篇文章中，我们想讨论PD中的各种表观遗传学变化，以及miRNA如何参与这些机制的调节，以及它们作为PD新治疗靶点的潜力。

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来源期刊

Mechanisms of Ageing and Development 医学-老年医学

CiteScore

11.10

自引率

1.90%

发文量

审稿时长

32 days

期刊介绍： Mechanisms of Ageing and Development is a multidisciplinary journal aimed at revealing the molecular, biochemical and biological mechanisms that underlie the processes of aging and development in various species as well as of age-associated diseases. Emphasis is placed on investigations that delineate the contribution of macromolecular damage and cytotoxicity, genetic programs, epigenetics and genetic instability, mitochondrial function, alterations of metabolism and innovative anti-aging approaches. For all of the mentioned studies it is necessary to address the underlying mechanisms. Mechanisms of Ageing and Development publishes original research, review and mini-review articles. The journal also publishes Special Issues that focus on emerging research areas. Special issues may include all types of articles following peered review. Proposals should be sent directly to the Editor-in-Chief.