Regulatory pathway underpinning the development of encephalitis after simian immunodeficiency virus infection in rhesus macaques (Macaca mulatta)

IF 0.8 4区农林科学 Q3 VETERINARY SCIENCES

Journal of Medical Primatology Pub Date : 2023-06-05 DOI:10.1111/jmp.12656

Taeho Kwon, Hong-Yi Xiang, Xiao-Ya Xing, Peng Jiang, Shuai-Yang Sun, Hu-Nan Sun, Ying-Hao Han

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引用次数: 0

Abstract

Background

Simian immunodeficiency virus (SIV) infection in rhesus macaques (Macaca mulatta) can lead to the development of SIV encephalitis (SIVE), which is closely related to human immunodeficiency virus (HIV)-induced dementia.

Methods

This was done by analyzing SIV and SIVE encephalitis in infected M. mulatta hippocampus samples from two microarray data sets, identifying two groups of common differentially expressed genes and predicting associated protein interactions.

Results

We found that eight genes—MX1, B2M, IFIT1, TYMP, STAT1, IFI44, ISG15, and IFI27—affected the negative regulation of biological processes, hepatitis C and Epstein–Barr viral infection, and the toll-like receptor signaling pathway, which mediate the development of encephalitis after SIV infection. In particular, STAT1 played a central role in the process by regulating biopathological changes during the development of SIVE.

Conclusion

These findings provide a new theoretical basis for the treatment of encephalopathy after HIV infection by targeting STAT1.

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猕猴猴免疫缺陷病毒感染后脑炎发生的调控途径

背景恒河猴（Macacamulatta）感染猴免疫缺陷病毒（SIV）可导致SIV脑炎的发展，这与人类免疫缺陷病毒（HIV）诱导的痴呆密切相关。方法通过分析来自两个微阵列数据集的受感染穆拉塔马样本中的SIV和SIV脑炎，鉴定两组常见的差异表达基因，并预测相关的蛋白质相互作用。结果我们发现8个基因——MX1、B2M、IFIT1、TYMP、STAT1、IFI44、ISG15和IFI27——影响生物过程、丙型肝炎和EB病毒感染的负调控，以及介导SIV感染后脑炎发展的toll样受体信号通路。特别是，STAT1通过调节SIVE发展过程中的生物病理学变化，在这一过程中发挥着核心作用。结论这些发现为靶向STAT1治疗HIV感染后脑病提供了新的理论依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Primatology 生物-动物学

CiteScore

1.40

自引率

42.90%

发文量

审稿时长

6 months

期刊介绍： The Journal of Medical Primatology publishes research on non-human primates as models to study, prevent, and/or treat human diseases; subjects include veterinary medicine; morphology, physiology, reproductive biology, central nervous system, and cardiovascular diseases; husbandry, handling, experimental methodology, and management of non-human primate colonies and laboratories; non-human primate wildlife management; and behaviour and sociology as related to medical conditions and captive non-human primate needs. Published material includes: Original Manuscripts - research results; Case Reports - scientific documentation of a single clinical study; Short Papers - case histories, methodologies, and techniques of particular interest; Letters to the Editor - opinions, controversies and sporadic scientific observations; Perspectives – opinion piece about existing research on a particular topic; Minireviews – a concise review of existing literature; Book Reviews by invitation; Special Issues containing selected papers from specialized meetings; and Editorials and memoriams authored by the Editor-in-Chief.