Sex steroid receptors in the ovarian follicles of the lizard Sceloporus torquatus.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-08-01 DOI:10.1017/S096719942300028X

Norma Berenice Cruz-Cano, Uriel Ángel Sánchez-Rivera, Carmen Álvarez-Rodríguez, Mario Cárdenas-León, Martín Martínez-Torres

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引用次数: 1

Abstract

Estradiol and progesterone have been recognized as important mediators of reproductive events in the female mainly via binding to their receptors. This study aimed to characterize the immunolocalization of the estrogen receptor alfa (ERα), estrogen receptor beta (ERβ) and progesterone receptor (PR) in the ovarian follicles of the lizard Sceloporus torquatus. The localization of steroid receptors has a spatio-temporal pattern that depends on the stage of follicular development. The immunostaining intensity of the three receptors was high in the pyriform cells and the cortex of the oocyte of previtellogenic follicles. During the vitellogenic phase, the granulosa and theca immunostaining was intense even with the modification of the follicular layer. In the preovulatory follicles, the receptors were found in yolk and additionally, ERα was also located in the theca. These observations suggest a role for sex steroids in regulating follicular development in lizards, like other vertebrates.

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蜥蜴卵巢卵泡内的性类固醇受体。

雌二醇和黄体酮主要通过与其受体的结合而被认为是女性生殖事件的重要介质。本研究旨在研究雌性激素受体α (ERα)、雌性激素受体β (ERβ)和孕激素受体(PR)在蜥蜴卵巢卵泡中的免疫定位。类固醇受体的定位具有时空模式，这取决于卵泡发育的阶段。三种受体在梨状细胞和卵泡前卵母细胞皮层的免疫染色强度较高。在卵黄形成期，即使卵泡层被修饰，颗粒和卵膜的免疫染色也很强烈。在排卵前卵泡中，受体主要位于卵黄中，此外，ERα也位于卵膜中。这些观察结果表明，与其他脊椎动物一样，性类固醇在调节蜥蜴的卵泡发育中发挥了作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.