Quantitative sensory testing: a good tool to identify subclinical neuropathy in ATTRV30M amyloidosis patients?

IF 5.2 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Amyloid-Journal of Protein Folding Disorders Pub Date : 2023-06-01 DOI:10.1080/13506129.2022.2155132

Isabel Conceição, Isabel de Castro, Andrés Diaz, José Castro

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引用次数: 3

Abstract

Background: Quantitative sensory testing (QST) has been one of the neurophysiological tools used for follow-up and disease progression assessment in ATTRv amyloidosis. We aimed to detect the utility of QST in identifying subclinical neuropathic involvement in ATTRV30M amyloidosis carriers.

Methods: A cohort of ATTRV30M amyloidosis carriers were assessed with vibratory (VDT) and cooling (CDT) detection thresholds and heat pain responses. Subjects were divided into asymptomatic carriers (Group 1), paucisymptomatic carriers (Group 2) and stage 1 ATTRv-PN patients (Group 3). Nonparametric statistics were used for group comparisons.

Results: A total of 207 ATTRV30M amyloidosis carriers (83 males) were included. Of these, 113 subjects were asymptomatic and 94 symptomatic carriers. In asymptomatic carriers, CDT and Heat Pain (HP 5.0 and HP 0.5) were significantly lower when compared to both group of symptomatic carriers (p ≤ 0.005). In Group 3, VDT, CDT and HP 5.0 were significantly higher, when compared to Group 2 (p < 0.05).

Conclusions: QST, in particular CDT, HP 5 and HP 0.5 modalities, seems a good tool to identify subclinical neuropathy in ATTRv amyloidosis carriers, with CDT showing a higher sensitivity to detect and early neuropathic involvement.

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定量感觉测试:鉴别ATTRV30M淀粉样变性患者亚临床神经病变的好工具?

背景:定量感觉测试(QST)已成为ATTRv淀粉样变性患者随访和疾病进展评估的神经生理学工具之一。我们的目的是检测QST在识别ATTRV30M淀粉样变携带者的亚临床神经病变参与方面的效用。方法:采用振动(VDT)和冷却(CDT)检测阈值和热痛反应对一组ATTRV30M淀粉样变携带者进行评估。将受试者分为无症状携带者(1组)、无症状携带者(2组)和一期ATTRv-PN患者(3组)。组间比较采用非参数统计。结果:共纳入ATTRV30M淀粉样变携带者207例(男性83例)。其中无症状113例，有症状携带者94例。在无症状携带者中，CDT和热痛(HP 5.0和HP 0.5)与两组有症状携带者相比显著降低(p≤0.005)。在第3组中，VDT、CDT和HP 5.0明显高于第2组(p结论:QST，特别是CDT、HP 5和HP 0.5模式，似乎是识别ATTRv淀粉样变携带者亚临床神经病变的良好工具，CDT在检测和早期神经病变累及方面表现出更高的敏感性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Amyloid-Journal of Protein Folding Disorders 生物-生化与分子生物学

CiteScore

10.60

自引率

10.90%

发文量

审稿时长

6-12 weeks

期刊介绍： Amyloid: the Journal of Protein Folding Disorders is dedicated to the study of all aspects of the protein groups and associated disorders that are classified as the amyloidoses as well as other disorders associated with abnormal protein folding. The journals major focus points are: etiology, pathogenesis, histopathology, chemical structure, nature of fibrillogenesis; whilst also publishing papers on the basic and chemical genetic aspects of many of these disorders. Amyloid is recognised as one of the leading publications on amyloid protein classifications and the associated disorders, as well as clinical studies on all aspects of amyloid related neurodegenerative diseases and major clinical studies on inherited amyloidosis, especially those related to transthyretin. The Journal also publishes book reviews, meeting reports, editorials, thesis abstracts, review articles and symposia in the various areas listed above.