Expansion and collapse of VEGF diversity in major clades of the animal kingdom

IF 9.2 1区医学 Q1 PERIPHERAL VASCULAR DISEASE

Angiogenesis Pub Date : 2023-04-05 DOI:10.1007/s10456-023-09874-9

Khushbu Rauniyar, Honey Bokharaie, Michael Jeltsch

{"title":"Expansion and collapse of VEGF diversity in major clades of the animal kingdom","authors":"Khushbu Rauniyar, Honey Bokharaie, Michael Jeltsch","doi":"10.1007/s10456-023-09874-9","DOIUrl":null,"url":null,"abstract":"<div><p>Together with the platelet-derived growth factors (PDGFs), the vascular endothelial growth factors (VEGFs) form the PDGF/VEGF subgroup among cystine knot growth factors. The evolutionary relationships within this subgroup have not been examined thoroughly to date. Here, we comprehensively analyze the PDGF/VEGF growth factors throughout all animal phyla and propose a phylogenetic tree. Vertebrate whole-genome duplications play a role in expanding PDGF/VEGF diversity, but several limited duplications are necessary to account for the temporal pattern of emergence. The phylogenetically oldest PDGF/VEGF-like growth factor likely featured a C-terminus with a BR3P signature, a hallmark of the modern-day lymphangiogenic growth factors VEGF-C and VEGF-D. Some younger VEGF genes, such as <i>VEGFB</i> and <i>PGF</i>, appeared completely absent in important vertebrate clades such as birds and amphibia, respectively. In contrast, individual PDGF/VEGF gene duplications frequently occurred in fish on top of the known fish-specific whole-genome duplications. The lack of precise counterparts for human genes poses limitations but also offers opportunities for research using organisms that diverge considerably from humans.</p><h3>Graphical abstract</h3><p>Sources for the graphical abstract: 326 MYA and older [1]; 72–240 MYA [2]; 235–65 MYA [3]</p>\n <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\n </div>","PeriodicalId":7886,"journal":{"name":"Angiogenesis","volume":"26 3","pages":"437 - 461"},"PeriodicalIF":9.2000,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10456-023-09874-9.pdf","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Angiogenesis","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s10456-023-09874-9","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}

引用次数: 1

Abstract

Together with the platelet-derived growth factors (PDGFs), the vascular endothelial growth factors (VEGFs) form the PDGF/VEGF subgroup among cystine knot growth factors. The evolutionary relationships within this subgroup have not been examined thoroughly to date. Here, we comprehensively analyze the PDGF/VEGF growth factors throughout all animal phyla and propose a phylogenetic tree. Vertebrate whole-genome duplications play a role in expanding PDGF/VEGF diversity, but several limited duplications are necessary to account for the temporal pattern of emergence. The phylogenetically oldest PDGF/VEGF-like growth factor likely featured a C-terminus with a BR3P signature, a hallmark of the modern-day lymphangiogenic growth factors VEGF-C and VEGF-D. Some younger VEGF genes, such as VEGFB and PGF, appeared completely absent in important vertebrate clades such as birds and amphibia, respectively. In contrast, individual PDGF/VEGF gene duplications frequently occurred in fish on top of the known fish-specific whole-genome duplications. The lack of precise counterparts for human genes poses limitations but also offers opportunities for research using organisms that diverge considerably from humans.

Graphical abstract

Sources for the graphical abstract: 326 MYA and older [1]; 72–240 MYA [2]; 235–65 MYA [3]

Abstract Image

查看原文本刊更多论文

动物界主要分支中VEGF多样性的扩展和崩溃

血管内皮生长因子（VEGF）与血小板衍生生长因子（PDGF）一起形成胱氨酸结生长因子中的PDGF/VEGF亚组。到目前为止，这个亚组中的进化关系还没有得到彻底的研究。在这里，我们全面分析了所有动物门的PDGF/VEGF生长因子，并提出了一个系统发育树。脊椎动物全基因组重复在扩大PDGF/VEGF多样性方面发挥作用，但有必要进行几种有限的重复来解释出现的时间模式。系统发育史上最古老的PDGF/VEGF样生长因子可能具有BR3P特征的C末端，这是现代淋巴管生成生长因子VEGF-C和VEGF-D的标志。一些较年轻的VEGF基因，如VEGFB和PGF，分别在鸟类和两栖动物等重要脊椎动物分支中完全缺失。相比之下，在已知的鱼类特异性全基因组重复之外，鱼类中经常发生个体PDGF/VEGF基因重复。人类基因缺乏精确的对应物造成了限制，但也为使用与人类有很大差异的生物体进行研究提供了机会。图形摘要图形摘要来源：326 MYA及以上[1]；72–240 MYA[2]；235–65 MYA[3]

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Angiogenesis PERIPHERAL VASCULAR DISEASE-

CiteScore

21.90

自引率

8.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Angiogenesis, a renowned international journal, seeks to publish high-quality original articles and reviews on the cellular and molecular mechanisms governing angiogenesis in both normal and pathological conditions. By serving as a primary platform for swift communication within the field of angiogenesis research, this multidisciplinary journal showcases pioneering experimental studies utilizing molecular techniques, in vitro methods, animal models, and clinical investigations into angiogenic diseases. Furthermore, Angiogenesis sheds light on cutting-edge therapeutic strategies for promoting or inhibiting angiogenesis, while also highlighting fresh markers and techniques for disease diagnosis and prognosis.