Nectins and Nectin-like molecules drive vascular development and barrier function

IF 9.2 1区 医学 Q1 PERIPHERAL VASCULAR DISEASE
Doryssa Hermans, Carla Rodriguez-Mogeda, Hannelore Kemps, Annelies Bronckaers, Helga E. de Vries, Bieke Broux
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引用次数: 1

Abstract

Angiogenesis, barriergenesis, and immune cell migration are all key physiological events that are dependent on the functional characteristics of the vascular endothelium. The protein family of Nectins and Nectin-like molecules (Necls) is a group of cell adhesion molecules that are widely expressed by different endothelial cell types. The family includes four Nectins (Nectin-1 to -4) and five Necls (Necl-1 to -5) that either interact with each other by forming homo- and heterotypical interactions or bind to ligands expressed within the immune system. Nectin and Necl proteins are mainly described to play a role in cancer immunology and in the development of the nervous system. However, Nectins and Necls are underestimated players in the formation of blood vessels, their barrier properties, and in guiding transendothelial migration of leukocytes. This review summarizes their role in supporting the endothelial barrier through their function in angiogenesis, cell–cell junction formation, and immune cell migration. In addition, this review provides a detailed overview of the expression patterns of Nectins and Necls in the vascular endothelium.

Abstract Image

凝集素和类凝集素分子驱动血管发育和屏障功能
血管生成、屏障生成和免疫细胞迁移都是依赖于血管内皮功能特征的关键生理事件。Nectin和Nectin样分子的蛋白质家族(Necls)是一组细胞粘附分子,在不同类型的内皮细胞中广泛表达。该家族包括四种Nectin(Nectin-1至-4)和五种Necls(Necl-1至-5),它们通过形成同源和异型相互作用而相互作用,或者与免疫系统内表达的配体结合。Nectin和Necl蛋白主要被描述为在癌症免疫学和神经系统发育中发挥作用。然而,Nectins和Necls在血管形成、屏障特性和引导白细胞跨内皮迁移方面被低估了。本文综述了它们通过在血管生成、细胞-细胞连接形成和免疫细胞迁移中的功能来支持内皮屏障的作用。此外,这篇综述提供了Nectins和Necls在血管内皮中表达模式的详细概述。
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来源期刊
Angiogenesis
Angiogenesis PERIPHERAL VASCULAR DISEASE-
CiteScore
21.90
自引率
8.20%
发文量
37
审稿时长
6-12 weeks
期刊介绍: Angiogenesis, a renowned international journal, seeks to publish high-quality original articles and reviews on the cellular and molecular mechanisms governing angiogenesis in both normal and pathological conditions. By serving as a primary platform for swift communication within the field of angiogenesis research, this multidisciplinary journal showcases pioneering experimental studies utilizing molecular techniques, in vitro methods, animal models, and clinical investigations into angiogenic diseases. Furthermore, Angiogenesis sheds light on cutting-edge therapeutic strategies for promoting or inhibiting angiogenesis, while also highlighting fresh markers and techniques for disease diagnosis and prognosis.
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