Strategies to improve the efficiency and quality of mutant breeding using heavy-ion beam irradiation.

IF 8.1 2区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Critical Reviews in Biotechnology Pub Date : 2024-08-01 Epub Date: 2023-07-16 DOI:10.1080/07388551.2023.2226339
Xiaopeng Guo, Junle Ren, Xiang Zhou, Miaomiao Zhang, Cairong Lei, Ran Chai, Lingxi Zhang, Dong Lu
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引用次数: 0

Abstract

Heavy-ion beam irradiation (HIBI) is useful for generating new germplasm in plants and microorganisms due to its ability to induce high mutagenesis rate, broad mutagenesis spectrum, and excellent stability of mutants. However, due to the random mutagenesis and associated mutant breeding modalities, it is imperative to improve HIBI-based mutant breeding efficiency and quality. This review discusses and summarizes the findings of existing theoretical and technical studies and presents a set of tandem strategies to enable efficient and high-quality HIBI-based mutant breeding practices. These strategies: adjust the mutation-inducing techniques, regulate cellular response states, formulate high-throughput screening schemes, and apply the generated superior genetic elements to genetic engineering approaches, thereby, improving the implications and expanding the scope of HIBI-based mutant breeding. These strategies aim to improve the mutagenesis rate, screening efficiency, and utilization of positive mutations. Here, we propose a model based on the integration of these strategies that would leverage the advantages of HIBI while compensating for its present shortcomings. Owing to the unique advantages of HIBI in creating high-quality genetic resources, we believe this review will contribute toward improving HIBI-based breeding.

利用重离子束辐照提高突变体培育效率和质量的策略。
重离子束辐照(HIBI)具有诱变率高、诱变谱广、突变体稳定性好等特点,可用于植物和微生物新种质的培育。然而,由于随机诱变和相关的突变体育种模式,提高基于 HIBI 的突变体育种效率和质量势在必行。本综述讨论并总结了现有理论和技术研究的结果,并提出了一套串联策略,以实现高效和高质量的基于 HIBI 的突变体育种实践。这些策略包括:调整突变诱导技术、调节细胞反应状态、制定高通量筛选方案,以及将产生的优良遗传元件应用于基因工程方法,从而提高基于 HIBI 的突变体培育的意义并扩大其范围。这些策略旨在提高诱变率、筛选效率和阳性突变的利用率。在此,我们提出一种基于这些策略整合的模式,既能发挥 HIBI 的优势,又能弥补其目前的不足。鉴于 HIBI 在创造优质遗传资源方面的独特优势,我们相信本综述将有助于改进基于 HIBI 的育种工作。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Critical Reviews in Biotechnology
Critical Reviews in Biotechnology 工程技术-生物工程与应用微生物
CiteScore
20.80
自引率
1.10%
发文量
71
审稿时长
4.8 months
期刊介绍: Biotechnological techniques, from fermentation to genetic manipulation, have become increasingly relevant to the food and beverage, fuel production, chemical and pharmaceutical, and waste management industries. Consequently, academic as well as industrial institutions need to keep abreast of the concepts, data, and methodologies evolved by continuing research. This journal provides a forum of critical evaluation of recent and current publications and, periodically, for state-of-the-art reports from various geographic areas around the world. Contributing authors are recognized experts in their fields, and each article is reviewed by an objective expert to ensure accuracy and objectivity of the presentation.
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