Early neurodevelopment in the offspring of women enrolled in a randomized controlled trial assessing the effectiveness of a nutrition + exercise intervention on the cognitive development of 12-month-olds.

IF 1.8 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Journal of Developmental Origins of Health and Disease Pub Date : 2023-08-01 Epub Date: 2023-07-14 DOI:10.1017/S204017442300020X

Neda Mortaji, John Krzeczkowski, Stephanie Atkinson, Bahar Amani, Louis A Schmidt, Ryan J Van Lieshout

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引用次数: 0

Abstract

Experimental data on the effects of lifestyle interventions on fetal neurodevelopment in humans remain scarce. This study assessed the impact of a pregnancy nutrition+exercise intervention on offspring neurodevelopment at 12 months of age. The Be Healthy in Pregnancy (BHIP) randomized controlled trial (RCT) randomly assigned pregnant persons with stratification by site and body mass index (BMI) to bi-weekly nutrition counselling and high dairy protein diet, walking goal of 10,000 steps/day plus usual prenatal care (UPC; intervention group) or UPC alone (control group). This study examined a subset of these mothers (> 18 years, singleton pregnancy, BMI <40 kg/m², and enrolled by ≤12 weeks gestation) and their infants (intervention = 42, control = 32), assessing cognition, language, motor, social-emotional, and adaptive functioning at 12 months using the Bayley Scales of Infant and Toddler Development third edition (BSID-III) as the outcome measure. We also examined if maternal factors (prepregnancy BMI, gestational weight gain (GWG)) moderated associations. Expressive language (MD = 9.62, 95% CI = (9.05-10.18), p = 0.03, ƞ²p = 0.07) and general adaptive composite (GAC) scores (MD = 103.97, 95% CI = (100.31-107.63), p = 0.04, ƞ²p = 0.06) were higher in infants of mothers in the intervention group. Effect sizes were medium. However, mean cognitive, receptive language, motor, and social-emotional scale scores did not differ between groups. A structured and monitored nutrition+exercise intervention during pregnancy led to improved expressive language and general adaptive behavior in 12-month-olds, but not cognitive, receptive language, motor, or socioemotional functioning. While these experimental data are promising, further research is needed to determine the clinical utility of nutrition+exercise interventions for optimizing infant neurodevelopment.

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参与一项随机对照试验的女性后代的早期神经发育，该试验评估营养+运动干预对12个月大婴儿认知发育的有效性。

关于生活方式干预对人类胎儿神经发育影响的实验数据仍然很少。本研究评估了妊娠期营养+运动干预对12个月大后代神经发育的影响。怀孕期间保持健康（BHIP）随机对照试验（RCT）将按部位和体重指数（BMI）分层的孕妇随机分配到每两周一次的营养咨询和高乳蛋白饮食、每天10000步的步行目标加上常规产前护理（UPC；干预组）或单独的UPC（对照组）。这项研究检查了这些母亲（>18岁，单胎妊娠，BMI 2，妊娠≤12周时登记）及其婴儿（干预=42，对照=32）的子集，使用贝利婴幼儿发展量表第三版（BSID-III）作为结果衡量标准，评估了12个月时的认知、语言、运动、社会情感和适应功能。我们还研究了母体因素（孕前BMI、妊娠体重增加（GWG））是否调节了相关性。干预组中母亲的婴儿表达语言（MD=9.62，95%CI=（9.05-10.18），p=0.03，ƞ2p=0.07）和一般适应性复合（GAC）得分（MD=103.97，95%CI=“100.31-107.63”，p=0.04，\414\ 2p=0.06）较高。效果大小中等。然而，各组的平均认知、接受语言、运动和社会情绪量表得分没有差异。怀孕期间的结构化和监测营养+运动干预改善了12个月大婴儿的表达语言和一般适应行为，但没有改善认知、接受语言、运动或社会情感功能。虽然这些实验数据很有希望，但还需要进一步的研究来确定营养+运动干预对优化婴儿神经发育的临床效用。

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来源期刊

Journal of Developmental Origins of Health and Disease PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

3.80

自引率

0.00%

发文量

145

审稿时长

6-12 weeks

期刊介绍： JDOHaD publishes leading research in the field of Developmental Origins of Health and Disease (DOHaD). The Journal focuses on the environment during early pre-natal and post-natal animal and human development, interactions between environmental and genetic factors, including environmental toxicants, and their influence on health and disease risk throughout the lifespan. JDOHaD publishes work on developmental programming, fetal and neonatal biology and physiology, early life nutrition, especially during the first 1,000 days of life, human ecology and evolution and Gene-Environment Interactions. JDOHaD also accepts manuscripts that address the social determinants or education of health and disease risk as they relate to the early life period, as well as the economic and health care costs of a poor start to life. Accordingly, JDOHaD is multi-disciplinary, with contributions from basic scientists working in the fields of physiology, biochemistry and nutrition, endocrinology and metabolism, developmental biology, molecular biology/ epigenetics, human biology/ anthropology, and evolutionary developmental biology. Moreover clinicians, nutritionists, epidemiologists, social scientists, economists, public health specialists and policy makers are very welcome to submit manuscripts. The journal includes original research articles, short communications and reviews, and has regular themed issues, with guest editors; it is also a platform for conference/workshop reports, and for opinion, comment and interaction.