Intermittent preventive treatment with Sulfadoxine pyrimethamine for malaria: a global overview and challenges affecting optimal drug uptake in pregnant women.

IF 4.9 4区 医学 Q1 PARASITOLOGY
Pathogens and Global Health Pub Date : 2023-07-01 Epub Date: 2022-09-30 DOI:10.1080/20477724.2022.2128563
Rodrigue Roman Dongang Nana, Joseph Hawadak, Loick Pradel Kojom Foko, Amit Kumar, Shewta Chaudhry, Aditi Arya, Vineeta Singh
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引用次数: 6

Abstract

Malaria in Pregnancy (MiP) leading to morbidity and mortality is a major public health problem that poses significant risk to pregnant women and their fetus. To cope with this alarming situation, administration of Sulfadoxine-pyrimethamine (SP) drugs to pregnant women as an intermittent preventive treatment (IPT) from 16 weeks of gestation is recommended by the World Health Organization (WHO) guidelines. We conducted a comprehensive search of published articles related to MiP in last 10 years with predefined keywords or their synonyms. The mapping of malaria in pregnant women showed a prevalence rate up to 35% in many countries. Although IPTp-SP has been implemented in endemic regions since several years but the IPTp-SP coverage percentage vary from country to country and continue to remain below the target of 80%. Major reasons for low IPTp-SP involve gestational age at first prenatal visit, level of education, place of residence, knowledge of IPTp-SP benefits, and use of antenatal services. Several challenges including the emergence of septuple and octuple SP-resistant parasites is reported from many countries which make the prophylactic use of IPTp-SP currently debatable. This narrative review addresses the barriers for optimal use of IPTp-SP and discusses alternative approaches to increase the use and effectiveness of SP intervention for preventing MiP. The COVID pandemic has drastically affected the public health disrupting the management of diseases worldwide. In view of this, a brief summary of COVID impact on MiP situation is also included.

磺胺嘧啶嘧啶用于疟疾的间歇性预防性治疗:全球概况和影响孕妇最佳药物摄入的挑战。
导致发病率和死亡率的妊娠期疟疾是一个主要的公共卫生问题,对孕妇及其胎儿构成重大风险。为了应对这种令人担忧的情况,从16日起,孕妇服用磺胺多辛-乙胺嘧啶(SP)药物作为间歇性预防性治疗(IPT) 世界卫生组织(世界卫生组织)的指导方针建议怀孕几周。我们对过去10年中发表的与MiP相关的文章进行了全面搜索 带有预定义关键字或其同义词的年份。对孕妇疟疾的测绘显示,许多国家的疟疾流行率高达35%。尽管IPTp SP已经在流行地区实施了几年,但IPTp SP的覆盖率因国家而异,并继续低于80%的目标。IPTp SP低的主要原因包括第一次产前检查时的胎龄、教育水平、居住地、对IPTp SP益处的了解以及产前服务的使用。许多国家报告了一些挑战,包括出现对七倍和八倍SP具有耐药性的寄生虫,这使得IPTp SP的预防性使用目前存在争议。这篇叙述性综述探讨了最佳使用IPTp SP的障碍,并讨论了提高SP干预预防MiP的使用和有效性的替代方法。新冠肺炎疫情严重影响了公共卫生,扰乱了全球疾病管理。鉴于此,还简要总结了新冠肺炎对MiP情况的影响。
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来源期刊
Pathogens and Global Health
Pathogens and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-PARASITOLOGY
CiteScore
6.00
自引率
0.00%
发文量
60
审稿时长
6-12 weeks
期刊介绍: Pathogens and Global Health is a journal of infectious disease and public health that focuses on the translation of molecular, immunological, genomics and epidemiological knowledge into control measures for global health threat. The journal publishes original innovative research papers, reviews articles and interviews policy makers and opinion leaders on health subjects of international relevance. It provides a forum for scientific, ethical and political discussion of new innovative solutions for controlling and eradicating infectious diseases, with particular emphasis on those diseases affecting the poorest regions of the world.
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